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Chemie der Proteine



Proteine

Protein ist eine von Berzelius geprägte und aus dem griechischen "proteuein" (der Erste sein) abgeleitete Sammelbezeichnung für die Gruppe der Eiweißstoffe, zu denen eine Vielzahl einzelner Gruppen gehören.

Online verfügbare Informationen zur Biochemie der Proteine.

Weitere Informationen zum Thema und ähnliche Themengebiete sowie Informationsquellen in englischer Sprache finden Sie im Menüfeld am linken Bildrand.



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Vorlesungsskripten und Vorlesungsmaterialien


Kovalente Struktur von Proteinen und Nukleinsäure
Vorlesungsskript - Format: PDF - [d]

Peptide, Proteine, Eiweißstoffe
Ausführliches Vorlesungsskript. Universität Erlangen - Format: PDF - [d]

Pflanzliche Proteine
Einiges über pflanzliche Proteine. Botanik online - [d]

Proteinanalytik
… mit 2-D PAGE - Format: PDF - [d]

Proteinaufreinigung und Proteingewinnung
Vorlesungsmaterialien. Universität Hannover - Format: PDF - [d/e]

Proteinbiosynthese, Translation
Grundlagen. Botanik online - [d]

Proteinchemie
Einführung in die Proteinchemie: Schematische und sehr kurze Einführung in die grundlegenden Mechanismen der Proteinchemie - [d]

Proteinchemie
Vorlesungsmaterialien Chemische Biologie: Peptid- und Proteinchemie. Universität Leipzig - [d]

Proteine
Grundlagen: Aminosäuren, Peptide, Sekundärstrukturen, Tertiärstrukturen; Botanik online - [d]

Proteine: Entstehung, abiotische Bedingungen
Können unter abiotischen Bedingungen auch Makromoleküle entstehen?. Botanik online - [d]

Proteinreinigung
Vorlesungsskript. Universität Leipzig - Format: PDF - [d]

Proteinstruktur
Graphische Darstellung von Proteinstrukturen. Botanik online - [d]

Proteinstruktur
Einführung in die räumliche Struktur von Proteinen - Format: PDF - [d]

Proteinstruktur
Einführung in die räumliche Struktur von Proteinen. FH Merseburg - Format: PDF - [d]

Proteinstruktur
Ein kurzer Überblick. Universität Erlangen - Format: PDF - [d]

Struktur und Faltung von Proteinen
Vorlesungsmaterialien. Universität Halle-Wittenberg - Format: PDF - [d]



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Spezielle Teilinformationen


Proteine als Sonden
Proteine als analytische Hilfsmittel zur Lokalisation von Molekülen und zum Studium der molekularen Architektur der Zellen. Botanik online - [d]

Proteine von Menschenhand
Wie sich mit "Protein Engineering" ohne Tiere Antikörper gewinnen lassen. Universität Zürich - [d]



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Hilfsmittel und Daten für Labor und Praktikum


Proteinreinigung
Reinigung rekombinanter Proteine. Universität Frankfurt - Format: PDF - [d]

Proteinreinigung
Techniken der Protein-Reinigung - Format: PDF - [d]

Proteinreinigung
Grundlagen, Techniken. PSI - Format: PDF - [d]



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Praktikumsskripten, praktische Anleitungen


Biochemisches Praktikum
Sammlung mit Praktikumsversuchen - Format: PDF - [d]

ELISA
Immunologischer Nachweis von Hühnereiweiß. Universität Heidelberg - Format: PDF - [d]

Funktion der Proteine Ebony und Tan
Die Funktion der Proteine Ebony und Tan im visuellen System von Drosophila melanogaster - Format: PDF - [d]

Immuno-Affinitätschromatographie
Antikörper in der Molekularbiologie; Theorie. SwissEduc - Format: PDF - [d]

Mdl1p
Praktikumsskript. Universität Frankfurt - Format: PDF - [d]

Molekulare und zelluläre Signaltransduktion
NMR-spektroskopische Strukturaufklärung biologisch relevanter Proteine. FMP - Format: PDF - [d]

Proteinbestimmung mit Biuret und Folin Proteinbestimmung mit Biuret und Folin
… nach enzymatischer Spaltung von Casein. Universität Hannover - Format: PDF - [d]

Proteinbiochemische Methoden
Vorlesungsskript. Universität Greifswald - Format: PDF - [d]

Proteine
Mehrere Versuchsanleitungen. Universität Salzburg - Format: PDF - [d]

Proteine
Praktikumsskript. Universität Giessen - Format: PDF - [d]

Proteinreinigung
Praktikumsskript: Proteinbiochemische Methoden. TU Freiberg - Format: PDF - [d]

Proteinreinigung
Anleitungen - Format: PDF - [d]

Proteinreinigung und Charakterisierung
Prinzipien - Format: PDF - [d]

Ultrafiltration
Versuchsprotokoll - Format: PDF - [d]

Western-Blotting
Nachweis von Cytochrom P450-Isoformen mittels Western-Blotting. Universität Potsdam - Format: PDF - [d]



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Metabolismus, Stoffwechselwege


Stoffwechsel
... von Proteinen und Aminosäuren - Format: PDF - [d]



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Daten und Datenbanken


3-D Protein Structure
Databases and Tools for 3-D Protein Structure Comparison and Alignment (USA) [e] - [e]

AARS
Aminoacyl-tRNA Synthetase Database. A hypertext version of the database published in the 2000 Database Issue of the Nucleic Acids Research - [e]

ABCdb
Archaeal and Bacterial ABC transporter database - [e]

ASPD
ASPD (Artificial Selected Proteins/Peptides Database) is a curated database on selected from randomized pools proteins and peptides. Database access is realised by means of simple search system and SRS (Sequence Retrieval System). ASPD is integrated by means of hyperlinks with different databases (SWISS-PROT, PDB, PROSITE, ...) - [e]

BindingDB
The Binding Database is a public, web-accessible database of measured binding affinities, focusing chiefly on the interactions of protein considered to be drug-targets with small, drug-like molecules - [e]

BioMagResBank
BMRB's mission is to collect, archive, and disseminate (worldwide in the public domain) the important quantitative data derived from NMR spectroscopic investigations of biological macromolecules - [e]

BLAST
Basic Local Alignment Search Tool finds regions of local similarity between sequences. The program compares nucleotide or protein sequences to sequence databases and calculates the statistical significance of matches. BLAST can be used to infer functional and evolutionary relationships between sequences as well as help identify members of gene families - [e]

BMCD
Biological Macromolecule Crystallization Database and the NASA Archive for Protein Crystal Growth Data - [e]

BMRB
BioMagResBank. A Repository for Date from NMR Spectroscopy on Proteins, Peptides and Nucleic Acids - [e]

Brenda
The Comprehensive Enzyme Information System - [e]

Cambridge Crystallographic Data Centre
CCDC is dedicated to the advancement of chemistry and crystallography for the public benefit through providing high-quality information services and software - [e]

CATH
A hierarchical classification of protein domain structures, which clusters proteins at four major levels, Class(C), Architecture(A), Topology(T) and Homologous superfamily (H) - [e]

CDD
A Conserved Domain Database and Search Service - [e]

ClustalW
... is a general purpose multiple sequence alignment program for DNA or proteins. It produces biologically meaningful multiple sequence alignments of divergent sequences. It calculates the best match for the selected sequences, and lines them up so that the identities, similarities and differences can be seen. Evolutionary relationships can be seen via viewing Cladograms or Phylograms - [e]

Dali server
... is a network service for comparing protein structures in 3D. You submit the coordinates of a query protein structure and Dali compares them against those in the Protein Data Bank. A multiple alignment of structural neighbours is emailed back to you - [e]

DExH/D protein database
... is an attempt to gather information about the DExH/D protein family with particular emphasis on the biochemical and functional characteristics of these proteins - [e]

DIP
The DIP (Database of Interacting Proteins) database catalogs experimentally determined interactions between proteins. It combines information from a variety of sources to create a single, consistent set of protein-protein interactions - [e]

DSSP database
... is a database of secondary structure assignments (and much more) for all protein entries in the Protein Data Bank (PDB). DSSP is also the program that calculates DSSP entries from PDB entries - [e]

EMBL Nucleotide Sequence Database
The EMBL Nucleotide Sequence Database (also known as EMBL-Bank) constitutes Europe's primary nucleotide sequence resource. Main sources for DNA and RNA sequences are direct submissions from individual researchers, genome sequencing projects and patent applications - [e]

EMBL-Align Multiple Sequence Alignment Database
Sequence alignment data - [e]

ENZYME
... is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided - [e]

ExPASy Molecular Biology Server
The ExPASy (Expert Protein Analysis System) proteomics server of the Swiss Institute of Bioinformatics (SIB) is dedicated to the analysis of protein sequences and structures as well as 2-D PAGE - [e]

EXProt
... a database for proteins with an experimentally verified function - [e]

Fasta
Provides sequence similarity searching against nucleotide and protein databases using the FASTA programs. FASTA can be very specific when identifying long regions of low similarity especially for highly diverged sequences. You can also conduct sequence similarity searching against complete proteome or genome databases using the FASTA programs - [e]

GPCRDB
Molecular Class-Specific Information System (MCSIS) project - [e]

HEART-2DPAGE
The Human Myocardial Two-Dimensional Electrophoresis Protein Database is the two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) database for human heart proteins. It contains data on proteins identified on the 2-D PAGE maps of ventricle and atrium of human heart - [e]

Hits
... is a free database devoted to protein domains. It is also a collection of tools for the investigation of the relationships between protein sequences and motifs described on them - [e]

Huge
The HUGE protein database are expected to cover various sets of large human proteins of hitherto unidentified functions. They are likely to be involved in cellular structure/motility (such as cytoskeleton, membrane skeleton, and motor proteins), gene expression and nucleic acid metabolism, cell signaling/communication (such as cellular adhesion, signal transduction, channels, and receptors), and so on - [e]

IMGT
... is a high-quality integrated knowledge resource specialized in the immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), immunoglobulin superfamily (IgSF), major histocompatibility complex superfamily (MhcSF) and related proteins of the immune system (RPI) of human and other vertebrate species - [e]

IMGT/HLA Sequence Database
... provides a specialist database for sequences of the human major histocompatibility complex (HLA) and includes the official sequences for the WHO Nomenclature Committee For Factors of the HLA System. The IMGT/HLA Database is part of the international ImMunoGeneTics project (IMGT) - [e]

InBase
The Intein Database and Registry - [e]

InterPro
... is a database of protein families, domains and functional sites in which identifiable features found in known proteins can be applied to unknown protein sequences - [e]

Isostar
... stores knowledge about intermolecular interactions in the form of scatterplots - [e]

Kegg
Kyoto Encyclopedia of Genes and Genomes - [e]

LIGAND
KEGG LIGAND contains our knowledge on the universe of chemical substances and reactions that are relevant to life. It is a composite database currently consisting of COMPOUND, DRUG, GLYCAN, REACTION, RPAIR, and ENZYME databases - [e]

Ligand Gated Ion Channel Database
Ligand-Gated Ion Channels are transmembrane proteins that can exist under different conformations, at least one forming a pore through the membrane connecting the two neighbour compartments - [e]

MDB
... contains quantitative information on all the metal-containing sites available from structures in the PDB distribution. This database contains geometrical and molecular information that allows the classification and search of particular combinations of site characteristics - [e]

MEROPS database
... is an information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them - [e]

MetaFam
... is a comprehensive relational database of protein family information. This web-accessible resource integrates data from several primary sequence and secondary protein family databases - [e]

Metalloprotein Site Database & Browser
MDB contains quantitative information on all the metal-containing sites available from structures in the PDB distribution. This database contains geometrical and molecular information that allows the classification and search of particular combinations of site characteristics - [e]

MINT
... focuses on experimentally verified protein interactions mined from the scientific literature by expert curators - [e]

Mirage
Molecular Informatics Resource for the Analysis of Gene Expression) is a web site dedicated to methodologies, tools, and technologies relating to gene expression information - [e]

ModBase
A database of three-dimensional protein models calculated by comparative modeling - [e]

MPsrch
... is a biological sequence sequence comparison tool that implements the true Smith and Waterman algorithm. It runs a search on a HP/COMPAQ cluster, using single and parallelised versions of the software - [e]

MultAlin
Multiple sequence alignment - [e]

MutaProt
Comparison of PDB files which differ by point mutations - [e]

NDB
A repository of three-dimensional structural information about nucleic acids - [e]

Nuclear Protein Database
... is a searchable database of information on proteins that are localised to the nucleus of vertebrate cells. MRC - [e]

PDB
The RCSB PDB provides a variety of tools and resources for studying the structures of biological macromolecules and their relationships to sequence, function, and disease - [e]

PDBsum
… provides an at-a-glance overview of every macromolecular structure deposited in the Protein Data Bank (PDB), giving schematic diagrams of the molecules in each structure and of the interactions between them - [e]

Peptaibol Database
A Bioinformatics resource - [e]

Pfam
... is a large collection of protein families, each represented by multiple sequence alignments and hidden Markov models (HMMs) - [e]

Phospho.ELM
... is a database of experimentally verified phosphorylation sites in eukaryotic proteins - [e]

PIR
Protein Information Resource - [e]

PKR
The Protein Kinase Resource has been redesigned and expanded with new content and cross-links with other online resources. In addition, we have introduced several new technologies to integrate information search, retrieval and visualization - [e]

PlantsP
Functional Genomics of Plant Phosphorylation - [e]

PPSEARCH
Search your query sequence for protein motifs, rapidly compare your query protein sequence against all patterns stored in the PROSITE pattern database and determine what the function of an uncharacterised protein is. EBI - [e]

PredictProtein
... is a service for sequence analysis, structure and function prediction. When you submit any protein sequence PredictProtein retrieves similar sequences in the database and predicts aspects of protein structure and function - [e]

PRINTS
... is a compendium of protein fingerprints. A fingerprint is a group of conserved motifs used to characterise a protein family; its diagnostic power is refined by iterative scanning of a SWISS-PROT/TrEMBL composite - [e]

ProDom
... is a comprehensive set of protein domain families automatically generated from the SWISS-PROT and TrEMBL sequence databases - [e]

Promise
The Prosthetic groups and Metal Ions in Protein Active Sites Database - [e]

Prosite
... consists of documentation entries describing protein domains, families and functional sites as well as associated patterns and profiles to identify them - [e]

Protein Data Bank
The RCSB PDB provides a variety of tools and resources for studying the structures of biological macromolecules and their relationships to sequence, function, and disease - [e]

Protein Explorer
Explore any 3D macromolecular structure model (PDB file) - [e]

Protein Kinase Resource
PKR explores the functions, evolution and diversity of protein kinases, the key controllers of cell behavior - [e]

Protein Mutant Database
PMD covers natural as well as artificial mutants, including random and site-directed ones, for all proteins except members of the globin and immunoglobulin families - [e]

RCSB Protein Data Bank
A Resource for Studying Biological Macromolecules - [e]

RNase P Database
A compilation of RNase P sequences, sequence alignments, secondary structures, three-dimensional models, and accessory information - [e]

S/MARt DB
... collects information about scaffold/matrix attached regions and the nuclear matrix proteins that are supposed be involved in the interaction of these elements with the nuclear matrix. It covers the whole range from yeast to human - [e]

SBASE
Protein domain library - [e]

SCOP
Structural Classification of Proteins - [e]

SENTRA
A Database of Sensory Signal Transduction Proteins - [e]

SeqAnalRef
... is a bibliographic reference data bank relative to papers dealing with sequence analysis. This data bank stores the references of articles from the expanding field of mathematical and computer analysis of biomolecular sequences - [e]

Structure Finder
... is comprised of the search interfaces and the databases developed by the NDB Project - [e]

SWISS-2DPAGE
Two-dimensional polyacrylamide gel electrophoresis database - [e]

SWISS-MODEL Repository
... is a database of annotated three-dimensional comparative protein structure models generated by the fully automated homology-modelling pipeline SWISS-MODEL - [e]

SWISS-PROT
A curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases - [e]

SYSTERS
Protein Family Database, Release 4: Large-scale Protein Clustering based on Sequence Similarity - [e]

Telomerase Database
... is a Web-based tool for the study of structure, function, and evolution of the telomerase ribonucleoprotein - [e]

TRANSFAC
The Transcription Factor Database is a database containing mouse transcription factor genes and their related genes. It is intended to select transcription factor genes nonredundantly from entire Mouse genome - [e]

Vida
... contains a complete collection of homologous protein families derived from open reading frames from complete and partial virus genomes. For each family you can get an alignment of the conserved regions, functional and taxonomy information, and links to DNA sequences and structures - [e]

Webcutter
On-line tool for restriction mapping nucleotide sequences - [e]

WPDB
The Protein Data Bank Through Microsoft Windows. Software zur PDB-Datenbank (USA) [e] - [e]



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Software und Programme


AMBER
... refers to two things: a set of molecular mechanical force fields for the simulation of biomolecules (which are in the public domain, and are used in a variety of simulation programs); and a package of molecular simulation programs which includes source code and demos - [e]

AMBER
Nutzungshinweise, Universität Köln - [d]

CLC Combined Workbench
... creates a software environment enabling users to make a large number of advanced protein, DNA, and RNA sequence analyses, combined with smooth data management, and excellent graphical viewing and output options - [e]

EMBOSS
... is a free Open Source software analysis package specially developed for the needs of the molecular biology (e.g. EMBnet) user community. The software automatically copes with data in a variety of formats and even allows transparent retrieval of sequence data from the web. Also, as extensive libraries are provided with the package, it is a platform to allow other scientists to develop and release software in true open source spirit. EMBOSS also integrates a range of currently available packages and tools for sequence analysis into a seamless whole. EMBOSS breaks the historical trend towards commercial software packages - [e]

ENDscript
... is an interface grouping eight types of programs: BLAST; MULTALIN/ CLUSTALW; DSSP; CNS; ESPript; BOBSCRIPT/ MOLSCRIPT; DINO; PHYLODENDRON; PROFIT. It aims to produce from a single PDB file four PostScript figures containing most required sequence and structure information on a protein of known structure - [e]

ESPript
ESPript, Easy Sequencing in Postscript, is a utility to generate a pretty PostScript output from aligned sequences - [e]

ExPASy Proteomics Server
The ExPASy (Expert Protein Analysis System) proteomics server of the Swiss Institute of Bioinformatics (SIB) is dedicated to the analysis of protein sequences and structures as well as 2-D PAGE - [e]

ExPASy Tools
ExPASy Proteomics tools - [e]

iProClass
The iProClass database provides value-added information reports for UniProtKB and unique NCBI Entrez protein sequences in UniParc, with links to over 90 biological databases, including databases for protein families, functions and pathways, interactions, structures and structural classifications, genes and genomes, ontologies, literature, and taxonomy - [e]

iProLINK
The Integrated Protein Literature Information and Knowledge has been developed as a resource to facilitate text mining in the area of literature-based database curation, named entity recognition, and protein ontology development - [e]

IRECS
… is a program that predicts the conformation of protein side chains. It does so either using only backbone information or using additional template information about the side-chain conformations - [e]

MolScript
... is a program for displaying molecular 3D structures, such as proteins, in both schematic and detailed representations - [e]

OpenRasMol
Open Source versions of RasMol - [e]

PIRSF
The PIRSF concept is being used as a guiding principle to provide comprehensive and non-overlapping clustering of UniProtKB sequences into a hierarchical order to reflect their evolutionary relationships. The PIRSF classification system is based on whole proteins rather than on the component domains; therefore, it allows annotation of generic biochemical and specific biological functions, as well as classification of proteins without well-defined domains - [e]

Protein Family Databases
Link collection - [e]

Protein Software
Download - Seite - [e]

Protein Software
Download-Seite, ZDNET - [e]

Proteome - Scaffold Software
Confident Protein Identification: Scaffold software works with SEQUEST® or Mascot® to identify proteins from mass spectrometry data. Scaffold lets you validate the mass spec results both statistically and visually - [e]

PSORT
... provides links to the PSORT family of programs for subcellular localization prediction as well as other datasets and resources relevant to localization prediction - [e]

RasMol
... is a program for molecular graphics visualisation - [e]

Software Liste, Sammlung
The RCSB PDB provides a variety of tools and resources for studying the structures of biological macromolecules and their relationships to sequence, function, and disease - [e]

Softwareliste
Software im Bereich Chemie und Hinweise zum Gebrauch der Programme; Universität Köln - [d]

Swiss-PdbViewer
DeepView - Swiss-PdbViewer is an application that provides a user friendly interface allowing to analyze several proteins at the same time. The proteins can be superimposed in order to deduce structural alignments and compare their active sites or any other relevant parts. Amino acid mutations, H-bonds, angles and distances between atoms are easy to obtain thanks to the intuitive graphic and menu interface - [e]

UniProt
Universal Protein Resource is the world's most comprehensive catalog of information on proteins - [e]



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Journale, Fachzeitschriften


Current Protein and Peptide Science
The purpose of Current Protein & Peptide Science is to present summaries of specific aspects of research involving proteins, peptides, and interactions between the enzymes, especially proteases; the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. Bentham - [e]

Current Proteomics
... publishes review articles in all aspects of the fast-expanding field of proteomics. All areas of proteomics are covered together with the methodology, softwares, databases, technological advances and applications of proteomics, including functional proteomics. Bentham - [e]

EMBO Journal
... provides for rapid publication of full-length papers describing original research of general rather than specialist interest in molecular biology and related areas - [e]

Peptides
... is an international journal presenting original contributions on the chemistry, biochemistry, neurochemistry, endocrinology, gastroenterology, physiology, and pharmacology of peptides, as well as their neurological, psychological and behavioral effects. Elsevier - [e]

Protein and Peptide Letters
... publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Bentham - [e]

Protein Engineering Design and Selection
PEDS publishes research papers and review articles relevant to the engineering, design and selection of proteins for use in biotechnology and therapy, and for understanding fundamental properties of activity, stability, folding, misfolding and disease. Oxford University Press - [e]

Protein Expression and Purification
... is dedicated to providing a forum for information about protein isolation based on conventional fractionation as well as techniques employing various molecular biological procedures to increase protein expression. Elsevier - [e]

Protein Science
... serves as an international forum for publishing original reports on proteins in the broadest sense. The Journal aims to unify this field by cutting across established disciplinary lines and focusing on “protein-centered” science. The Protein Society - [e]

Proteins: Structure, Function, and Bioinformatics
... publishes original reports of significant experimental and analytic research in all areas of protein research: structure, function, computation, genetics, and design. Wiley-Interscience - [e]

Proteomics
... is the premier international source for information on all aspects of applications and technologies in proteomics. Wiley-Interscience - [e]

Regulatory Peptides
... provides a medium for the rapid publication of interdisciplinary studies on the physiology and pathology of peptides of the gut, endocrine and nervous systems which regulate cell or tissue function. Elsevier - [e]



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Dissertationen


Modellierung der Tertiärstrukturen lysosomaler Cysteinproteasen
Charakterisierung der katalytisch aktiven Bindungszentren und strukturbasiertes Ligandendesign; Online-Dissertation, 2000, Uni Halle - [d]

Proteinstruktur und Proteinentfaltungsanalysen ...
... mit Hilfe der Ramanspektroskopie: Untersuchung an Modellpeptiden zur Optimierung der Methodik. Dissertation, PDF-Format, Universität Bremen, 2000 - [d]



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Newsarchiv


Der Terahertz-Tanz des Wassers mit den Proteinen
Protein-Einfluss hat eine unvermutet große Reichweite. Es ist besonders die Art der Faltung, die bei Proteinen ihre Funktion bestimmt - ein dynamischer Prozess, der sehr schnell abläuft. Bei der Untersuchung dieses "Tanzes" der Proteine hat man bislang den Partner außer Acht gelassen: das Wasser. Dieses Zusammenspiel zwischen Wasser und Proteinen haben Forscher aus Bochum, Illinois und Nevada um Prof. Dr. Martina Havenith-Newen (Physikalische Chemie II der RUB) nun mittels Terahertz-Spektroskopie beobachtet. - [d]

Magnetische Effekte in Eisen-Schwefel-Proteinen
Eiweißmoleküle, die kleine magnetische Zentren aus Eisenatomen enthalten, spielen eine wichtige Rolle beim Energiefluss in lebenden Organismen. Forscher um Prof. Dr. Dominik Marx (Lehrstuhl für Theoretische Chemie der Ruhr-Universität) haben nun erstmals gezeigt, dass die magnetischen Eigenschaften dieser Zentren eng an die Dynamik der Proteinumgebung gekoppelt sind. Diese aufgrund einer neuen mehrskaligen Simulationstechnik gewonnenen Ergebnisse wurden nun in den renommierten "Proceedings of the National Academy of Sciences" (PNAS) publiziert. - [d]

Neues Verfahren vermisst aktive Zentren von Proteinen
Mit einer speziellen Methode für gepulste EPR-Spektroskopie bei hohen Magnetfeldern gelang es Wissenschaftlern erstmals, die genaue Orientierung der aktiven Zentren eines Proteinkomplexes zu vermessen. - [d]

RUB-Chemiker "verfilmen" die Proteinfaltung
Neue KITA-Spektroskopie erlaubt Echtzeit-Beobachtung. Artikel, August 2008.
Bild [Quelle: RUB, Wiley]: Die kinetische Terahertz-Absorption (KITA) verwendet Pikosekundenpulse, um Solvatationsdynamiken während Selbstorganisationsprozessen auf der Zeitskala zwischen Millisekunden bis Sekunden zu erfassen. Die Anwendung der Methode zur Untersuchung der Umorganisation des Wassersolvats bei der Faltung eines Proteins (hier: Ubiquitin) beschreiben M. Gruebele et al. in der Angewandte Chemie. - [d]



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Institute und Foschungseinrichtungen


Halle-Wittenberg
Arbeitsgruppe Proteintechnologie an der Martin-Luther-Universität Halle-Wittenberg - [e]

Max Planck Research Unit for Enzymology of Protein Folding
Forschungszentrum der Max-Planck-Gesellschaft - [e]

Proteinstrukturfabrik
Initiative des Deutschen Humangenomprojekts (DHGP) - [e]

UltraStrukturNetzwerk
USN ist ein Projekt, das durch das MPI für Molekulare Genetik in Kooperation mit der Charité 2002 initiiert wurde. - [d]





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Verlinkung:
www.internetchemie.info/chemie/proteine.htm
Einträge:
165
Thema:
Chemie der Proteine
Stichworte:
Proteine, Proteomik, Proteinbiochemie, Daten, Forschung
Stand:
24.02.2012 00:00:00 [Überprüfung der Links]
 
14.09.2013 [Änderung der Seite]



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Literatur- und Buchempfehlungen zum Thema Proteine:


Buchempfehlung

Hubert Rehm

Der Experimentator: Proteinbiochemie / Proteomics

Die überarbeitete und aktualisierte 5. Auflage dieses Buches gibt Ihnen einen Überblick über die Methoden in Proteinbiochemie und Proteomics. Das Buch ist jedoch mehr als eine Methodensammlung: Es zeigt Auswege aus experimentellen Sackgassen und weckt ein Gespür für das richtige Experiment zur richtigen Zeit. Dies in klarem knappem Deutsch.

Behandelt werden klassische Verfahren wie Säulenchromatographie, HPLC, Elektrophoresen, Blots, Elisas, Ligandenbindungstests, die Herstellung von Antikörpern, das Solubilisieren von Membranproteinen, die Analyse von Glykoproteinen usw. Das Buch beschränkt sich nicht auf die Standardverfahren, die jeder kennt. Es gibt Ihnen einen Vorteil, indem es auch auf ausgefallene Methoden hinweist, mit denen sich spezielle Probleme lösen lassen. Einen großen Raum nehmen die modernen Verfahren ein: Massenspektrometrie, Proteomics und thermische Analyse. In der 5. Auflage wurden besonders das Kapitel Proteomics und darin die Angaben zur Massenspektrometrie überarbeitet und erweitert.

Es wird Ihnen auffallen, dass der Autor Lust und Frust der Laborroutine kennt. Die eingestreuten Don Quichotte Sprüche und der lockere Stil des Autors werden Ihnen über die Tiefpunkte des manchmal rauen Forscheralltags hinweghelfen.

Spektrum Akademischer Verlag; 2006


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