Toxikogenomik, Genotoxizität

 |

Aktuelle Berichte

 |

Allgemeine Informationen und Grundlagen

Toxikogenomik
Der Einsatz von Genexpressionsanalysen für die Risikobewertung von Chemikalien. Artikel: Fachgruppe Umweltchemie und Ökotoxikologie, 2003. TU Braunschweig - [d]

 |

Daten und Datenbanken

Comparative Toxicogenomics Database, CTD
The CTD elucidates molecular mechanisms by which environmental chemicals affect human disease - [e]

Database Development in Toxicogenomics
Issues and Efforts. Environmental Health Perspectives Volume 112, Number 4, March 2004 - [e]

 |

Toxikologie, Medizin, Physiologie

ToxFX™ Analysis Suite
... provides a complete toxicogenomics solution to help researchers better understand compound safety issues in early drug discovery and development. - [e]

 |

Institute und Foschungseinrichtungen

Fraunhofer ITEM
Fraunhofer Institut für Toxikologie und Experimentelle Medizin - [d, e]

Hannover
Professur für Pharmakogenomik und Toxikogenomik an der Medizinischen Hochschule Hannover - [d, e]

NCTR Center for Toxicoinformatics
The goal of the toxicoinformatics group is to develop methods for the analysis and integration of omics (genomic, transcriptomic, proteomic, and metabolomic) databases with the objective of knowledge discovery and the elucidation of mechanisms of toxicity - [e]

Toxicogenomics Laboratory
Toxic Substances in the Environment. UC Berkeley - [e]

Universitätseinrichtungen
... für Toxikologie in Deutschland, Österreich und der Schweiz. Liste der GTFCH - [d]

 |

Organisationen, Verbände

European Bioinformatics Institute: NET Project
The NET Project works to maximize the interactions between Nutrigenomics, Environmental genomics and Toxicogenomics (NET) communities and their collective NETworking capability with EBI groups - [e]

Niederlande
The Netherlands Toxicogenomics Centre, NTC, aims to employ toxicogenomics to increase the basic understanding of toxicological mechanisms towards developing new and better test methods - [e]

OECD
Activities to Explore and Evaluate Regulatory Application of Genomic Methods; Toxicogenomics - [e]

Toxicogenomics Research Consortium
Enhancement of research in the broad area of environmental stress responses using microarray gene expression profiling - [e]

WHO
International Programme on Chemical Safety - Toxicogenomics - [e]

Sonstige Hinweise:

Literatur- und Buchempfehlungen zum Thema Toxikogenomik:

Saura Sahu

Toxicogenomics: A Powerful Tool for Toxicity Assessment

"Toxicogenomics: A Powerful Tool For Toxicity Testing" provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology.Topics covered include: mechanistic toxicogenomics; analysis and interpretation of toxicogenomic data; principles of data mining in toxicogenomics; design issues in toxicogenomics studies; sources of variability in toxicogenomic assays Escherichia coli stress response as a tool for detection of toxicity; toxicogenomics as a tool to assess immunotoxicity; toxicogenomics and ecogenomics for studying endocrine disruption and basic biology; use of toxicogenomics as an early predictive tool for hepatotoxicity; nutrigenomics - the application of genomic signatures in nutrition-related research; application of toxicogenomics in drug discovery; potential uses of toxicogenomic biomarkers in occupational health and risk assessment; usefulness of toxicogenomics in the regulatory environment; and, perspectives on toxicogenomics at the US Environmental Protection Agency.

Wiley-Blackwell; 2008