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Toxicogenomics

Toxicogenomics is a scientific discipline and research area that studies how the genome is involved in responses to environmental stressors and toxicants. It combines toxicology with genomics to understand the role of gene-environment interactions in diseases, and also offers the opportunity to develop tests that require fewer laboratory animals or cause them less inconvenience

Further information categories about related topics are listed in the navigation menu on the left side of these page.

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Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment
NAS report offers new tools to assess health risks from chemicals; Oct 2007 - [USA > e]

Genetic Terms
Dictionary of Genetic Terms: Genomics and Its Impact on Medicine and Society - [USA > e]

Genetic Terms
The National Human Genome Research Institute (NHGRI) created the Talking Glossary of Genetic Terms to help people without scientific backgrounds understand the terms and concepts used in genetic research - [USA > e]

Standardization initiatives in the (eco)toxicogenomics domain
A review in Comp Funct Genom 2004; 5: 633–641; Wiley; doi: 10.1002/cfg.447 - [e]

The Principles and Practice of Toxicogenomics
Applications and Opportunities. Article by the Society of Toxicology; 2000 - [USA > e]

Toxicogenomics
Poster Presentations. EPA - [USA > e]

Toxicogenomics
An Overview of Toxicogenomics. Article: Curr. Issues Mol. Biol. (2002) 4: 45-56 - [USA > e]

Toxicogenomics - An Emerging Discipline
Article: Environmental Health Perspectives; EHP - [USA > e]

Toxicogenomics in Drug Development
Article: Toxicologic Pathology, 31:471–479, 2003 - [USA > e]

Toxicogenomics in Risk Assessment
Assessing the utility, challenges, and next steps; 2006 - [e]

Toxicogenomics: History and Current Applications
Linking genetic makeup to drug responsiveness could lead to better, safer therapies while enhancing drug discovery and development. Article, ASM News; 2004 - [USA > e]

What is toxicogenomics
PDF Article - [USA > e]

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DNA Microarray Technology
Fact sheet - [USA > e]

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Comparative Toxicogenomics Database, CTD
The CTD elucidates molecular mechanisms by which environmental chemicals affect human disease - [USA > e]

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ToxFX™ Analysis Suite
... provides a complete toxicogenomics solution to help researchers better understand compound safety issues in early drug discovery and development. Affymetrix - [USA > e]

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Application of toxicogenomics to the endocrine disruption issue
Article: Pure Appl. Chem., Vol. 75, Nos. 11–12, pp. 2419–2422, 2003. IUPAC - [USA > e]

Database Development in Toxicogenomics: Issues and Efforts
Article: Environmental Health Perspectives. EHP - [USA > e]

Practical Application of Toxicogenomics in Early Drug Discovery
Article, Abbott 2007 - [e]

Toxicogenomics in the assessment of immunotoxicity
Article, Elsevier, doi 10.1016/j.ymeth.2006.07.010; 2006 - [e]

Toxicogenomics: Articles
Environmental Health Perspectives Volume 112, Number 16, November 2004 - [USA > e]

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European Bioinformatics Institute: NET Project
The NET Project works to maximize the interactions between Nutrigenomics, Environmental genomics and Toxicogenomics (NET) communities and their collective NETworking capability with EBI groups - [UK > e]

Hannover, Germany
Chair for Pharmaco- and Toxicogenomics at Hannover Medical School, MHH - [D > d, e]

Netherlands
The Netherlands Toxicogenomics Centre, NTC, aims to employ toxicogenomics to increase the basic understanding of toxicological mechanisms towards developing new and better test methods - [NL > e]

Toxicogenomics Laboratory
Toxic Substances in the Environment. UC Berkeley - [USA > e]

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National Center for Toxicogenomics
Research Center at NIEHS - [USA > e]

NCTR Center for Toxicoinformatics
The goal of the toxicoinformatics group is to develop methods for the analysis and integration of omics (genomic, transcriptomic, proteomic, and metabolomic) databases with the objective of knowledge discovery and the elucidation of mechanisms of toxicity. FDA - [USA > e]

OECD
Activities to Explore and Evaluate Regulatory Application of Genomic Methods; Toxicogenomics - [INT > e]

Toxicogenomics Research Consortium
Enhancement of research in the broad area of environmental stress responses using microarray gene expression profiling - [USA > e]

WHO
International Programme on Chemical Safety - Toxicogenomics - [INT > e]

Sonstige Hinweise:

Related Books and Scientific Literature: Toxicogenomics:

Saura Sahu

Toxicogenomics: A Powerful Tool for Toxicity Assessment

"Toxicogenomics: A Powerful Tool For Toxicity Testing" provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology.Topics covered include: mechanistic toxicogenomics; analysis and interpretation of toxicogenomic data; principles of data mining in toxicogenomics; design issues in toxicogenomics studies; sources of variability in toxicogenomic assays Escherichia coli stress response as a tool for detection of toxicity; toxicogenomics as a tool to assess immunotoxicity; toxicogenomics and ecogenomics for studying endocrine disruption and basic biology; use of toxicogenomics as an early predictive tool for hepatotoxicity; nutrigenomics - the application of genomic signatures in nutrition-related research; application of toxicogenomics in drug discovery; potential uses of toxicogenomic biomarkers in occupational health and risk assessment; usefulness of toxicogenomics in the regulatory environment; and, perspectives on toxicogenomics at the US Environmental Protection Agency.

Wiley-Blackwell; 2008