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Chemistry News Archive February 2009


 
Chemistry News February 2009

News of the year 2009 in the fields of chemistry and chemistry-related topics like biochemistry, nantechnology, medicinal chemistry etc.

Main focus: press releases, scientific research results and summaries of chemistry articles, that are published in chemistry journals.

Please send us a eMail to publish your press release!


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Chemistry

 

Gold-palladium nanoparticles achieve greener, smarter production of hydrogen peroxide
Processing in smaller quantities and more useful concentrations is seen.

 
Artificial photosystem

Plugging in Molecular Wires

It?s all in the wiring: biocomponents at the heart of an artificial photosystem.

Image:

Electrons released by irradiation of PSI and transmitted along the wire are very efficiently transmitted to the gold electrode by the viologen group.

[Image credit: Wiley]



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Physics - Fundamental Research

 

New technique boosts protein NMR imaging speeds
A researcher believes he has found a quicker and more efficient approach to using SSNMR called paramagnetic relaxation-assisted condensed data collection, or PACC.



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Chemistry & Biology

 
Model of the folding energy landscape for cytochrome c

Caltech and UCSD researchers shed light on how proteins find their shapes

The researchers bring together theoretical models and experimental data to explain protein folding.

Image: The UCSD model of the folding energy landscape for cytochrome c. The landscape was probed experimentally at Caltech, using time-resolved fluorescence energy transfer from six donor labels (represented as single spheres of differing colors) to the heme acceptor.

[Credit: Peter Weinkam, UCSD].

 
Stereoselective Synthesis of Enantiomerically Pure Nupharamine Alkaloids

The Beaver as Chemist

Total synthesis of enantiomerically pure nupharamine alkaloids from castoreum [Image source: Wiley]

 
Primitive artificial cell created with lipid membrane and two large molecules

Artificial cells, simple model for complex structure

A simple, chemical materials model may lead to a better understanding of the structure and organization of the cell according to a Penn State researcher.

Image:

Primitive artificial cell created with lipid membrane and two large molecules.

[Credit: Christine Keating, Penn State]

 
Uranium-binding protein

A Pocketful of Uranium

Construction of a selective uranium-binding protein.

Image: This NikR mutant only binds to DNA in the presence of uranyl, not in the presence of nickel or other metal ions.

[Image credit: Wiley]

 

How cells handle broken chromosomes
Scientists from the Max Planck Institute of Biochemistry discovered a novel cellular response towards persistent DNA damage.

 

Enzyme cocktail converts cellulosic materials, water into hydrogen fuel
Tomorrow's fuel-cell vehicles may be powered by enzymes that consume cellulose from woodchips or grass and exhale hydrogen.

 
HSP 70

Fox Chase Researchers Give Mutants Another Chance

Study demonstrates how it might be possible to restore the function of a mutant gene without altering DNA.

[Image credit: Fox Chase Cancer Center].

 
Aldehyde tag

Tailor-made Recombinant Proteins in Mammals

Aldehyde tags put chemical modifications where they?re needed.

Image:

DNA for the core sequence of six amino acids ? leucine, cysteine, threonine, proline, serine, and arginine (red letters) ? is cloned into the gene for the recombinant protein at the locus to be chemically modified.

[Image credit: LBL]

 
Cyclic AMP receptor protein (CRP)

Long-Sought Protein Structure May Help Reveal How ?Gene Switch? Works

NIST, Brookhaven Researchers Use Tuberculosis Bacteria to End 25-Year Quest.

Image:

Computer model of the defined structure for the "off" state of the cyclic AMP receptor protein (CRP) found in Mycobacterium tuberculosis

[Credit: Travis Gallagher, NIST].

 

Discovery fleshes out metabolism of key environmental and energy bacteria
Results in Shewanella reveal new multi-protein enzyme in many bacterial species.

 
Researchers achieve semisynthesis of homogeneous glycoproteins

Enzyme with a Sugar Antenna

Researchers achieve semisynthesis of homogeneous glycoproteins.

[Image credit: Wiley].

 
Serotonin

Serotonin brings locusts together

Role of brain chemical on locust swarming revealed in Science.



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Chemistry & Medicine

 

Light Instead of Current
Activation of neurons with light by means of semiconductor photoelectrodes.

 

No longer a gray area
Our hair bleaches itself as we grow older.

 

Houseplant pest gives clue to potential new anthrax treatment
Researchers at the University of Warwick have found how a citric acid-based Achilles heel used by a pathogen that attacks the popular African Violet house plant could be exploited not just to save African Violets but also to provide a potentially effective treatment for Anthrax.

 

Case Western Reserve researchers develop 'wireless' activation of brain circuits
Burda and Strowbridge offer firsrt report of brain stimulation using light-activated semiconductor nanoparticles.

 

Mechanisms that prevent Alzheimer's Disease: Enzymatic activity plays key role
Journal of Alzheimer's Disease (JAD) publishes new findings on the protective effects of the enzyme alpha-secretase.

 

Even natural perfumes may cause allergies
Hypersensitivity to perfumes is the most common contact allergy in adults. Research at the University of Gothenburg, Sweden has demonstrated that even natural aromatic oils, which many deem harmless compared to synthetic perfumes, may cause allergic reactions.

 

Researchers disrupt biochemical system involved
Small molecule - mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.



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Chemistry & Materials

 

Chemists offer new hydrogen purification method
Mesoporous germanium-rich chalcogenido frameworks with highly polarizable surfaces and relevance to gas separation.

 

Viscosity-enhancing nanomaterials may double service life of concrete
NIST engineers are patenting a method that is expected to double the service life of concrete. The key is a nano-sized additive.

 

Nanoscopic static electricity generates chiral patterns
In the tiny world of amino acids and proteins and in the helical shape of DNA, a biological phenomenon abounds ...



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Chemistry & Nanotechnology

 

New imaging technique reveals the atomic structure of nanocrystals
A new imaging technique developed by researchers at the University of Illinois overcomes the limit of diffraction and can reveal the atomic structure of a single nanocrystal with a resolution of less than one angstrom (less than one hundred-millionth of a centimeter).

 
New Nano-Structures

Sophisticated nano-structures assembled with magnets

What do Saturn and flowers have in common?

By manipulating the magnetization of a liquid solution, the researchers have for the first time coaxed magnetic and non-magnetic materials to form intricate nano-structures

Image:

Saturn/Flowers New Nano-Structures.

[Image credit: Duke University]

 
Silver nanoparticle mirror

Beaming new light on life

From beetles to aircraft, nanoparticles aid microscope views.

Image: A silver nanoparticle mirror is held next to a US penny for scale.

[Image by John Lupton, University of Utah]

 

Rice rolls out new nanocars
Fluorescent imaging shows models operate at room temperature.



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ACS News (open access articles):

 

 

Egg-irony: High cholesterol food may reduce blood pressure

Eggs

Eggs might reduce high blood pressure, scientists report.

Image credit: Wikipedia

Researchers in Canada are reporting evidence that eggs - often frowned upon for their high cholesterol content - may reduce another heart disease risk factor - high blood pressure.

They describe identification of egg proteins that act like a popular group of prescription medications in lowering blood pressure. The report appeared in the Feb. 11 issue of ACS' Journal of Agricultural and Food Chemistry, a bi-weekly publication.

In the new study, Jianping Wu and Kaustav Majumder note that eggs are an inexpensive source of high-quality protein and other nutrients. Egg consumption, however, has decreased during the last 40 years amid concerns about cholesterol. Recent studies do suggest that healthy people can eat eggs without increasing their heart disease risk. Other research hinted that certain egg proteins might have effects similar to ACE inhibitors, prescription drugs used to treat high blood pressure.

Pursuing that lead in laboratory studies, the scientists identified several different peptides in boiled and fried eggs that act as potent ACE inhibitors. The scientists showed that enzymes in the stomach and small intestine produce these peptides from eggs. Fried eggs had the highest ACE inhibitory activity. It will take studies in humans to determine if the egg proteins do lower blood pressure in people, the scientists emphasized. Funding for the research came from livestock and poultry industry groups. - MTS

Journal of Agricultural and Food Chemistry: "Angiotensin I Converting Enzyme Inhibitory Peptides from Simulated in Vitro Gastrointestinal Digestion of Cooked Eggs" [DOI: 10.1021/jf8028557].

 

New test to identify illegal steroids in cattle

In an effort to curb the illegal use of steroids in the European beef industry, scientists in the United Kingdom are reporting the development of a new test that can identify steroids with higher accuracy, more convenience, and less cost than conventional doping tests. Their report is in the current issue of Analytical Chemistry, a semi-monthly journal.

In the new study, Rodat Cunningham and colleagues note that the European Union banned use of growth-promoting agents in cattle. However, widespread abuse of steroids continues and remains difficult to detect, they say. The standard methods for detecting steroid abuse - mass spectrometry and gas chromatography - involve directly measuring these substances in cattle. But the tests are expensive and can't detect some of the newer steroid hormones.

The scientists describe a new test that measures steroids indirectly based on chemical changes associated with growth and muscle development in steroid-treated cattle. Using a commercial blood analyzer commonly found in hospitals, the researchers measured 20 chemical markers, including proteins and cholesterol, in cattle treated with and without commonly used steroids over a 42-day study period. The new test detected the steroids with accuracy between 91 and 96 percent. The study opens the door to on-site steroid testing with portable instrumentation, the researchers say. - MTS

Analytical Chemistry: "Feasibility of a Clinical Chemical Analysis Approach To Predict Misuse of Growth Promoting Hormones in Cattle" [DOI: 10.1021/ac801966g].

 

Injections of licorice ingredient show promise as treatment for cocaine addiction

Licorice

An ingredient in licorice shows promise as an antidote for the toxic effects of cocaine abuse.

Image credit: American Chemical Society

An ingredient in licorice shows promise as an antidote for the toxic effects of cocaine abuse, including deadly overdoses of the highly addictive drug, researchers in Korea and Pennsylvania are reporting. Their study is in the Jan. 2 issue of ACS' Journal of Proteome Research, a monthly publication.

In the new study, Meeyul Hwang, Chae Ha Yang, and colleagues note that there is currently no effective medicine for treating cocaine abuse or addiction. Recent animal studies conducted by the researchers show that a licorice ingredient called isoliquiritigenin (ISL) can block the nervous system's production of dopamine. That neurotransmitter is involved in emotion, movement, and other brain activities.

Cocaine and other addictive drugs stimulate dopamine and help produce the pleasurable and addictive effects. Drugs that block dopamine block this response. The scientists used rats as model animals to show that rats injected with ISL just prior to cocaine-administration showed 50 percent less of the behavioral effects associated with the illicit drug. They also showed that ISL injections protected nerve cells in the brain from cocaine-associated damage. - MTS

Journal of Proteome Research: "Proteomic and Behavioral Analysis of Response to Isoliquiritigenin in Brains of Acute Cocaine Treated Rats" [DOI: 10.1021/pr800237s].

 

Soybean product fights abnormal protein involved in Alzheimer's disease

Natto

An enzyme in natto, a soybean product, could help fight Alzheimer's disease, scientists say.

Image credit: Wikipedia

A vegan food renowned in Asia for its ability to protect against heart attacks also shows a powerful ability in lab experiments to prevent formation of the clumps of tangled protein involved in Alzheimer's disease, scientists in Taiwan are reporting. Their study is in the Feb. 11 issue of ACS' Journal of Agricultural and Food Chemistry, a bi-weekly publication.

Rita P. Y. Chen and colleagues point out that people in Asia have been eating natto - a fermented food made from boiled soybeans - for more than 1,000 years. Natto contains an enzyme, nattokinase, that has effects similar to clot-busting drugs used in heart disease.Nattokinase is sold a dietary supplement to improve the body's circulatory system. The scientists term this the first study on whether nattokinase also can dissolve amyloids. Those tangled proteins are involved in Alzheimer's disease and several other health problems.

In the study, the nattokinase degraded several kinds of amyloid fibrils, suggesting its possible use in the treatment of amyloid-related diseases. "Moreover, since natto has been ingested by humans for a long time, it would be worthwhile to carry out an epidemiological study on the rate of occurrence of various amyloid-related diseases in a population regularly consuming natto," the scientists say. - JS

Journal of Agricultural and Food Chemistry: "Amyloid-Degrading Ability of Nattokinase from Bacillus subtilis Natto" [DOI: 10.1021/jf803072r].

 

Ocean becoming more acidic, potentially threatening marine life

A dramatic increase in carbon dioxide levels is making the world's ocean more acidic, which may adversely affect the survival of marine life and organisms that depend on them, such as humans. An article on this topic is scheduled for the Feb. 23 issue of Chemical & Engineering News, ACS' weekly newsmagazine.

In the article, C&EN Associate Editor Rachel Petkewich notes that the increased use of fossil fuels has caused levels of carbon dioxide in the atmosphere to nearly double since the Industrial Revolution. The ocean absorbs large amounts of carbon dioxide - about 22 million tons a day - causing the water's pH to decrease or acidify. The pH scale measures how acidic or alkaline substances are. The pH scale ranges from 0 to 14. A pH of 7 is neutral. A pH less than 7 is acidic. A pH greater than 7 is alkaline. The ocean's pH is currently about 8.1, down from 8.2 in the 18th century, the article notes. Scientists project that the ocean's pH will fall by about 0.3 more units in the next 50 to 100 years.

Researchers worldwide are now reporting that these lower pH levels could affect many aspects of the biochemistry, development, and reproduction of marine organisms, including jellyfish, sea anemones, plankton, and coral. Lower pH levels may even affect the ability of the ocean to transmit sound, which could affect the way some mammals communicate by sonar, the article notes. "To what extent the oceans will continue to acidify is uncertain and whether marine organisms can adapt to the changes in store also remains to be seen," the article notes.

Chemical & Engineering News: "Off Balance Ocean".

 

New biomass heater: A "new era" of efficiency and sustainability

Charcoal Combustion Heater

This is a photo of the charcoal combustion heater that Japanese scientists say will offer cleaner, more efficient home heating.
[Image by Amit Suri]

Millions of homes in rural areas of Far Eastern countries are heated by charcoal burned on small, hibachi-style portable grills. Scientists in Japan are now reporting development of an improved "biomass charcoal combustion heater" that they say could open a new era in sustainable and ultra-high efficiency home heating. Their study was published in ACS' Industrial & Engineering Chemistry Research, a bi-weekly journal.

In the study, Amit Suri, Masayuki Horio and colleagues note that about 67 percent of Japan is covered with forests, with that biomass the nation's most abundant renewable energy source. Wider use of biomass could tap that sustainable source of fuel and by their calculations cut annual carbon dioxide emissions by 4.46 million tons.

Using waste biomass charcoal, their heater recorded a thermal efficiency of 60-81 percent compared to an efficiency of 46-54 percent of current biomass stoves in Turkey and the U.S. "The charcoal combustion heater developed in the present work, with its fast startup, high efficiency, and possible automated control, would open a new era of massive but small-scale biomass utilization for a sustainable society," the authors say. - JS

Industrial & Engineering Chemistry Research: "Development of Biomass Charcoal Combustion Heater for Household Utilization".

 

Antibacterial plaster could put a clean sheen on walls

Scientists in China are reporting development and testing of new self-sanitizing plaster with more powerful antibacterial effects than penicillin. The material could be used in wall coatings, paints, art works and other products. The study is in the current issue of ACS' Crystal Growth & Design, a bi-monthly journal.

Liang-jie Yuan and colleagues note that plaster has been used for centuries as building material and surfaces for great works of art, including Michelangelo's famed Sistine Chapel ceiling in Vatican City. The new, first-of-its kind plaster - formed from different ingredients from traditional gypsum plaster - still retains similar mechanical properties while having added antibacterial effects.

Lab tests showed that the so-called "supramolecular" plaster has a "very broad" antibacterial spectrum, killing five types of disease-causing bacteria. When compared with penicillin, the plaster was more effective at controlling growth of four kinds of bacteria, including dangerous Staphylococcus aureus and Escherichia coli. "It can be expected that the supramolecular plaster can be used for building, painting, coating and carving, and the coat, brick, or art ware constructed by the plaster do not need additive antiseptic or sterilization," the authors say. - JS

Crystal Growth & Design: "A Novel Supramolecular Plaster Based on An Organic Acid-Base Compound: Synthesis, Structure, Mechanical Properties, and Sterilizing Performance".

 

Information superhighway's trash yields a super highway asphalt

Materials from Printed Circuit Boards

Materials from printed circuit boards used in electronics, such as computers and cell phones, could be used to strengthen asphalt paving, scientists report. Above is a micrograph of the modified asphalt.

Image by The American Chemical Society

Discarded electronic hardware, including bits and pieces that built the information superhighway, can be recycled into an additive that makes super-strong asphalt paving material for real highways, researchers in China are reporting in a new study. It is scheduled for the Feb. 1 issue of ACS' Environmental Science & Technology, a semi-monthly journal. They describe development of a new recycling process that can convert discarded electronic circuit boards into an asphalt "modifier." The material makes high-performance paving material asphalt that is cheaper, longer lasting, and more environmentally friendly than conventional asphalt, the scientists report.

In the new study, Zhenming Xu and colleagues note that millions of tons of electronic waste (e-waste) pile up each year. The printed circuit boards used in personal computers, cell phones, and other electronic gear, contain toxic metals such as lead and mercury and pose a difficult disposal problem. The boards also are difficult to recycle. Xu's group, however, realized that the boards, which provide mechanical support and connections for transistors and other electronic components, contain glass fibers and plastic resins that could strengthen asphalt paving.

The scientists describe a new recycling method that quickly separates toxic metals from circuit boards, yielding a fine, metal-free powder. When mixed into asphalt in laboratory tests, the powder produced a stronger paving material less apt to soften at high temperatures, the researchers say. - MTS

Environmental Science & Technology: "Asphalt Modified with Nonmetals Separated from Pulverized Waste Printed Circuit Boards".

 

Frozen smoke: The ultimate sponge for cleaning up oil spills

Frozen smoke: aerogels

Aerogels, a super-lightweight solid sometimes called "frozen smoke," may capture oil from wastewater and soak up environmental oil spills.

Image by Wikipedia Commons

Scientists in Arizona and New Jersey are reporting that aerogels, a super-lightweight solid sometimes called "frozen smoke," may serve as the ultimate sponge for capturing oil from wastewater and effectively soaking up environmental oil spills. Their study is in ACS' Industrial & Engineering Chemistry Research, a bi-weekly journal.

In the new study, Robert Pfeffer and colleagues point out that the environmental challenges of oil contamination go beyond widely publicized maritime oil spills like the Exxon Valdez incident. Experts estimate that each year people dump more than 200 million gallons of used oil into sewers, streams, and backyards, resulting in polluted wastewater that is difficult to treat. Although there are many different sorbent materials for removing used oil, such as activated carbon, they are often costly and inefficient. Hydrophobic silica aerogels are highly porous and absorbent material, and seemed like an excellent oil sponge.

The scientists packed a batch of tiny aerogel beads into a vertical column and exposed them to flowing water containing soybean oil to simulate the filtration process at a wastewater treatment plant. They showed that the aerogel beads absorbed up to 7 times their weight and removed oil from the wastewater at high efficiency, better than many conventional sorbent materials. - MTS

Industrial & Engineering Chemistry Research: "Removal of Oil from Water by Inverse Fluidization of Aerogels".

 

Greener pesticides, better farming practices help reduce U.S. pesticide use

Although few consumers realize it, fruits, veggies, and other agricultural products marketed in the United States today are grown on farms that use less pesticide than 30 years ago, according to an article scheduled for the Feb. 16 issue of Chemical & Engineering News, ACS' weekly newsmagazine.

C&EN Senior Editor Stephen K. Ritter points out in the magazine's cover story that pesticide use has dropped in the U.S. due to more efficient pesticides and better agricultural practices. Pesticide use peaked at 1.46 billion pounds in 1979 and fell to 1.23 billion pounds in 2001 - the last year for which comprehensive data are available, according to the Environmental Protection Agency. Since then pesticide use has remained at those lower levels, the article states.

Several innovations are responsible for this decline in pesticide use, including better, more selective pesticides that can be applied at lower rates while having less impact on human health and the environment. Other factors include a farming practice called integrated pest management (IPM), which involves withholding the use of synthetic pesticides only until damage reaches a certain threshold. In addition, farmers also are using more so-called biopesticides. These natural substances, derived from plants, microorganisms, and insects, can combat noxious weeds, insects, and fungi with less harm to crops and the environment.

Chemical & Engineering News: "Greening The Farm".

 

Mars Rover device gets new mission on Earth

Mars Rover

This is the Mars Rover at the Udvar-Hazy Center of the National Air and Space Museum in Chantilly, Va.

[Credit: Wikipedia Commons]

Developed to sniff out extraterrestrial life on other planets, a portable device known as the Mars Organic Analyzer (MOA) is taking on a new role in detecting air pollutants on Earth. Researchers in California report the development of a modified MOA able to detect polycyclic aromatic hydrocarbons (PAHs), potentially carcinogenic molecules from cigarette smoke and wood smoke, volcanic ash, and other sources. The report appeared in the Jan. 15 issue of ACS' semi-monthly journal Analytical Chemistry.

In the report, Richard A. Mathies and colleagues indicate that current earthbound PAH detection focuses on the cleanup of environmental contamination sites. On other planets, the concentration of organic PAH molecules can provide valuable insight into environmental conditions and the potential for extraterrestrial life. But existing PAH detection methods are slow and costly. Scientists thus are seeking an inexpensive, rapid and nondestructive technique for the measurement of PAH contamination.

The researchers tested samples from Lake Erie and a hydrothermal vent from the Gulf of California, as well as a Martian analogue sample from the Mars-like Atacama Desert, one of the driest spots on earth. They found that the detection sensitivity of the device was on par with current laboratory methods. "The method of PAH analysis developed here significantly advances the MOA's capabilities for organic carbon detection and may also prove useful for environmental monitoring," says Mathies. - AD

Analytical Chemistry: "Polycyclic Aromatic Hydrocarbon Analysis with the Mars Organic Analyzer Microchip Capillary Electrophoresis System".

 

Natural solar collectors on butterfly wings inspire more powerful solar cells

A close-up of the scales of a butterfly wing

This is a close-up of the scales of a butterfly wing. These scales have inspired more powerful solar cells.

[Credit: Michael Apel, Wikipedia Commons]

The discovery that butterfly wings have scales that act as tiny solar collectors has led scientists in China and Japan to design a more efficient solar cell that could be used for powering homes, businesses, and other applications in the future. Their study appeared in the Jan. 13 issue of ACS' Chemistry of Materials, a bi-weekly journal.

In the study, Di Zhang and colleagues note that scientists are searching for new materials to improve light-harvesting in so-called dye-sensitized solar cells, also known as Gr?zel cells for inventor Michael Gr?zel. These cells have the highest light-conversion efficiencies among all solar cells - as high as 10 percent.

The researchers turned to the microscopic solar scales on butterfly wings in their search for improvements. Using natural butterfly wings as a mold or template, they made copies of the solar collectors and transferred those light-harvesting structures to Gr?zel cells. Laboratory tests showed that the butterfly wing solar collector absorbed light more efficiently than conventional dye-sensitized cells. The fabrication process is simpler and faster than other methods, and could be used to manufacture other commercially valuable devices, the researchers say. - MTS

Chemistry of Materials: "Novel Photoanode Structure Templated from Butterfly Wing Scales".

 

Nanotubes trigger biochemical "cross talk" for consumer protection tests

Researchers in West Virginia and Japan are reporting an advance toward a blood test that could help protect consumers from new products containing potentially harmful kinds of nanotubes. These ultra small wisps of carbon - 1/5,000th the width a single human hair - may become the basis for multibillion-dollar medical, consumer electronics, and other industries in the future.

Their report is appeared in the Jan. 14 issue of ACS' Nano Letters, a monthly journal.

Petia Simeonova and colleagues cite hints from past studies that nanotubes are toxic to the lungs of laboratory animals. Those findings emphasized the need for tests to check on the toxicity before products containing these particles hit the market.

In the new research, scientists deposited nanotubes in the lung of lab mice, and discovered the existence of a "cross-talk" mechanism, in which the animals' lungs alerted the rest of the body to the nanotubes presence. The alert caused specific genes in the animals to kick into action and produce certain proteins. The resulting biochemical signature of nanotube exposure could become a biomarker for exposure to harmful nanoparticles, the researchers say.  - MTS

Nano Letters: "Cross-Talk between Lung and Systemic Circulation during Carbon Nanotube Respiratory Exposure. Potential Biomarkers".

 

Toward "invisible electronics" and transparent displays

Researchers in California are reporting an advance toward the long-sought goal of "invisible electronics" and transparent displays, which can be highly desirable for heads-up displays, wind-shield displays, and electronic paper. The scientists describe development of tiny, transparent electronic circuits - the most powerful of their kind to date - that could pave the way for transparent electronics and other futuristic applications, including flexible electronic newspapers and wearable clothing displays. Their study appeared in the Jan. 27 issue of ACS Nano, a monthly journal.

In the new study, Chongwu Zhou and colleagues point out that although scientists have previously developed nano-sized transparent circuits, previous versions are limited to a handful of materials that are transparent semiconductors.

The researchers describe the development of transparent thin-film transistors (TTFTs) composed of highly aligned, single-walled carbon nanotubes - each about 1/50,000th the width of a single human hair. They are transparent, flexible, and perform well. Laboratory experiments showed that TTFTs could be easily applied to glass and plastic surfaces, and showed promise in other ways for a range of possible practical applications. - MTS

ACS Nano: "Transparent Electronics Based on Transfer Printed Aligned Carbon Nanotubes on Rigid and Flexible Substrates".

 

Nanoparticles in dietary supplements cause health concerns, regulatory challenges

An increase in the number of dietary supplements made with nanoparticles - so called "nanoceuticals" - is raising growing concerns about their potential for toxicity in the wake of little government oversight, according to an article scheduled for the Feb. 9 online issue of Chemical & Engineering News, ACS' weekly newsmagazine.

In the article, C&EN Associate Editor Britt Erickson notes that manufacturers of dietary supplements are increasingly using nano-sized particles (about 1/5000th the width of a single human hair) to boost nutrient absorption, enhance mental focus and creativity, and other health-promoting functions. One nonprofit organization that tracks nanotechnology estimates at least 44 "nanoceuticals" are currently on the market, quadruple the number that existed three years ago.

But consumers have no way of knowing whether a "nanoceutical" is safe or whether it does what it claims to do, the article notes. Unlike drugs, dietary supplements do not need to be reviewed by the Food and Drug Administration for safety and effectiveness before marketing. This lack of government oversight, coupled with growing concerns about the potential toxicity of nanoparticles, has led consumer groups to urge regulators to do more to ensure that nanoceuticals are safe and effective.

Notes one regulatory expert, "If FDA waits much longer, we are going to be faced with hundreds of products and hundreds of companies and a much more difficult situation."

Chemical & Engineering News: "Nanoceuticals".

 

Edible fungus foils dangerous grapefruit-drug interactions

Edible fungus

An edible fungus added to grapefruit juice could reduce side effects people have when drinking that juice while taking prescription drugs, scientists report.

Image credit: Royal Botanic Gardens, Melbourne

Scientists in Florida report that adding an edible mushroom-like fungus to grapefruit juice may help to reduce the serious side effects that can occur when people taking certain prescription drugs drink grapefruit juice. Their study is in the January 14 edition of the ACS' bi-weekly Journal of Agricultural and Food Chemistry.

In the study, Kyung Myung and colleagues explain that furanocoumarins (FCs) - chemicals found in grapefruit and some other citrus - block a key enzyme critical for metabolizing, or breaking down, certain prescription medications. This "grapefruit/drug" interaction - sometimes called the "grapefruit effect" - can turn normal drug doses into toxic overdoses. Researchers have tried to remove FCs using chemical, physical and microbiological methods. Myung and colleagues, for example, had previously discovered that an inedible fungus can be used to remove most of the FCs from grapefruit juice.

Now they report that the edible fungus Morchella esculenta, which is from the same major fungal group as the previously tested inedible fungus, removed most of the furanocoumarins from the grapefruit juice. It also reduced grapefruit juice's inhibition of the enzyme by 60 percent. Dried M. esculenta also worked, leading the researchers to suggest that it could be useful in removing the compound from grapefruit juice and identifying the specific components in the fungi that bind to furanocoumarins. - KSD

Journal of Agricultural and Food Chemistry: "Removal of Furanocoumarins in Grapefruit Juice by Edible Fungi".

 

Toward a urine test for diagnosing heart disease

Researchers in Australia are reporting an advance toward the first urine test for diagnosing coronary artery disease (CAD), the condition responsible for most of the 1.5 million heart attacks that occur in the United States each year. The test could save lives in the future by allowing earlier diagnosis and monitoring of the disease, which is the No. 1 cause of death in the United States, the researchers say. Their report is in the Nov. 19, 2008 issue of ACS' Journal of Proteome Research, a monthly publication.

In the new study, Karlheinze Peter and colleagues note that the most reliable test for diagnosing CAD is angiography, an invasive test in which doctors inject special dyes into the body to visualize, via X-rays, fatty plaque deposits in the arteries of the heart. However, the technique is invasive, expensive, time-consuming, and may miss CAD in its earliest stages, they say.

To develop a faster, more convenient test, the scientists collected urine samples from a group of 67 patients - 41 with CAD and 26 without - and analyzed the samples for differences in protein content. Using a newly developed method, they identified a group of 17 peptides (building blocks of proteins) that appear to be directly associated with CAD. These urine-based peptides indicated the presence of the disease with an 84 percent accuracy rate when compared to CAD cases confirmed using angiography, the researchers say, underscoring their potential for diagnostic screening. - MTS

Journal of Proteome Research: "Evaluation of Urine Proteome Pattern Analysis for Its Potential To Reflect Coronary Artery Atherosclerosis in Symptomatic Patients".

 

Burying crop residues at sea may help reduce global warming

Carbon dioxide

Burying crop residues at sea may help reduce carbon dioxide levels in an effort to fight global warming.

Image credit: iStockphoto

Imagine a massive international effort to combat global warming by reducing carbon dioxide - build up in the atmosphere. It involves gathering billions of tons of cornstalks, wheat straw, and other crop residue from farm fields, bailing it, shipping the material to seaports, and then burying it in the deep ocean. Scientists in Washington and California have concluded that this Crop Residue Oceanic Permanent Sequestration (CROPS) approach is the only practical method now available for permanently sequestering, or isolating, the enormous quantities of CO2 necessary to have a real impact on global warming.

In a report scheduled for the Feb. 15 issue of ACS' Environmental Science & Technology, a semi-monthly journal, Stuart Strand and Gregory Benford conclude that (CROPS) could reduce global carbon dioxide accumulation by up to 15 percent per year. Plants remove carbon dioxide from the atmosphere during photosynthesis, and release it when they decay. Ocean burial would prevent that carbon dioxide from re-entering the atmosphere.

After comparing known methods for carbon dioxide sequestration on the basis of efficiency, long-term effectiveness, practicality, and cost, the researchers concluded that CROPS is the only method feasible with existing technology. CROPS would be 92 percent efficient in sequestering crop residue carbon. They recommend that crop residue sequestration and its effects on the ocean should be investigated further and its implementation encouraged. - MTS

Environmental Science & Technology: "Ocean Sequestration of Crop Residue Carbon: Recycling Fossil Fuel Carbon Back to Deep Sediments".

 

Quantum dots may be toxic to cells, environment under certain conditions

Researchers in Texas are reporting that quantum dots (QDs) - a product of the revolution in nanotechnology increasingly used in electronics, solar cells, and medical imaging devices - may be toxic to cells under acidic or alkaline conditions. Their study, the first to report on how different pH levels may affect the safety of QDs, appears in the Jan.15 issue of ACS' Environmental Science & Technology, a semi-monthly journal.

In the new study, Pedro Alvarez, Shaily Mahendra, and colleagues note that QDs are semiconductor nanocrystals composed of a metal core surrounded by a shell composed of zinc or cadmium sulfide.

Scientists are increasingly concerned that these submicroscopic dots, about 1/50,000th the width of a human hair, could decompose during normal use or after disposal. That decomposition could release toxic metals into the environment, posing a health risk to humans and animals.

To explore this concern, the scientists exposed two common types of bacteria that serve as models of cell toxicity and indicators of environmental health to QDs under different conditions of acidity and alkalinity. At near neutral pH levels, bacteria exposed to QDs experienced decreased rates of growth, but did not die. However, at moderately acidic or alkaline conditions, many of the QD-exposed bacteria died as QDs shells decomposed, releasing their content of toxic metals. However, proteins and natural organic matter may be able to mitigate toxicity by complexing metal ions or coating particles. The study cautions, "the release of toxic inorganic constituents during their weathering under acidic or alkaline conditions in the human body or the environment may cause unintended harm that might be difficult to predict with short-term toxicity tests." - MTS

Environmental Science & Technology: "Quantum Dot Weathering Results in Microbial Toxicity".

 

New NASCAR materials may save lives on the race track and highway

New materials for NASCAR promise to save lives and reduce injuries in automobile racing - a popular sport with a fan-base of 75 million - and everyday driving, according to an article scheduled for the Feb. 2 issue of Chemical & Engineering News, ACS' weekly newsmagazine. NASCAR's new racing season begins Feb. 7.

In the magazine's cover story, C&EN Associate Editor Bethany Halford points out that for many years NASCAR (the National Association for Stock Car Auto Racing) left safety innovations in the hands of mechanics and engineers tinkering in the garage. These innovations haven't kept pace with NASCAR's push for faster cars, the article notes. But a series of spectacular crashes that claimed the lives of several NASCAR stars brought about a new focus on safety.Researchers recently established the NASCAR R&D Center to focus on safety innovations, leading to a major redesign of the stockcar to make it more crash resistant. Other innovations include clothing (for drivers and crews) that is more fire-resistant and the development of stronger safety barriers for the track walls. Some of these materials could be used in future passenger cars and highways, the article suggests.

Chemical & Engineering News: "Materials for the Modern Gladiator".



Chemistry news archive - ordered by month


2009:

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Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

2008:

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Mar

Apr

May

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Aug

Sep

Oct

Nov

Dec




 


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March 02, 2010

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Chemistry, news archive, February, 2009

 

 

 

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