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The research was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Selective Chemical Intervention in Biological Systems Initiative. In the latest research, when Manchester researchers added synthetic molecules, they bound to the riboswitches and caused the genes to spark into life. The findings are reported in the lProceedings of the National Academy of Sciences (PNAS). The Manchester team monitored how successfully they had re-wired the cells by observing the creation of a gene product that makes the cells glow green. Dr Neil Dixon, a senior researcher in the team, said: "Being able to selectively activate and regulate genes could have tremendous impact in drug discovery and the emerging field of synthetic biology. "This technology could be used to turn on and off important biological pathways and processes, leading to a deeper understanding of how cells function. "The next big challenge is to apply this technology to study biological processes within human cells. This could allow us to discover more about our hugely complex biological selves." The Manchester team is now working on ways to simultaneously activate and control multiple genes using these re-wired riboswitches.
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