Medicinal Chemistry: Current Research Articles

 
Current research articles in the field of Medicinal Chemistry published in online journals.

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On this page considered biochemistry journals:

Journal of Medicinal Chemistry - published by The American Chemical Society, ACS -
As the most cited journal in Medicinal Chemistry, the Journal of Medicinal Chemistry focuses on original research dealing with chemical-biological relationships, mainly the bond between molecular structure and biological activity.

Enzyme Inhibition and Medicinal Chem - published by Taylor & Francis -
... is an international and interdisciplinary vehicle publishing new knowledge and findings on enzyme inhibitors and inhibitory processes and agonist/antagonist receptor interactions in the development of medicinal and anti-cancer agents and an understanding of their action.

Medicinal Chemistry Research - published by Springer -
... offers prompt publication of novel experimental achievements in the many facets of drug design, drug discovery, and the elucidation of mechanisms of action of biologically active compounds.

Current research articles of the mentioned journals:

Discovery of 2-Chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a Potent Inducer of Apoptosis with High In Vivo Activity Nilantha Sirisoma, Shailaja Kasibhatla, Azra Pervin, Hong Zhang, Songchun Jiang, J. Adam Willardsen, Mark B. Anderson, Vijay Baichwal, Gary G. Mather, Kevin Jessing, Raouf Hussain, Khanh Hoang, Christopher M. Pleiman, Ben Tseng, John Drewe, and Sui Xiong Cai Web Release Date: Thu, 24 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm8003653 Source: Journal of Medicinal Chemistry | 24 Jul 2008 | 6:00 am CEST

Journal of Medicinal Chemistry Journal of Medicinal Chemistry, Volume 51 Issue 14 (July 24, 2008) is now available Source: Journal of Medicinal Chemistry | 24 Jul 2008 | 6:00 am CEST

Synthesis of GABAA Receptor Agonists and Evaluation of their α-Subunit Selectivity and Orientation in the GABA Binding Site Michaela Jansen, Holger Rabe, Axelle Strehless, Sandra Dieler, Fabian Debus, Gerd Dannhardt, Myles H. Akabas, and Hartmut Lüddens Web Release Date: Thu, 24 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm701562x Source: Journal of Medicinal Chemistry | 24 Jul 2008 | 6:00 am CEST

Design, Synthesis and Biological Evaluation of Glutathione Peptidomimetics as Components of Anti-Parkinson Prodrugs Swati S. More and Robert Vince Web Release Date: Thu, 24 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800239v Source: Journal of Medicinal Chemistry | 24 Jul 2008 | 6:00 am CEST

Discovery of a Novel Series of Benzoic Acid Derivatives as Potent and Selective Human β3 Adrenergic Receptor Agonists with Good Oral Bioavailability. 3. Phenylethanolaminotetraline (PEAT) Skeleton Containing Biphenyl or Biphenyl Ether Moiety Masashi Imanishi, Yutaka Nakajima, Yasuyo Tomishima, Hitoshi Hamashima, Kenichi Washizuka, Minoru Sakurai, Shigeo Matsui, Emiko Imamura, Koji Ueshima, Takao Yamamoto, Nobuhiro Yamamoto, Hirofumi Ishikawa, Keiko Nakano, Naoko Unami, Kaori Hamada, Yasuhiro Matsumura, Fujiko Takamura, and Kouji Hattori Web Release Date: Thu, 24 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800222k Source: Journal of Medicinal Chemistry | 24 Jul 2008 | 6:00 am CEST

Design of a Sialylglycopolymer with a Chitosan Backbone Having Efficient Inhibitory Activity against Influenza Virus Infection Myco Umemura, Masae Itoh, Yutaka Makimura, Kohji Yamazaki, Midori Umekawa, Ayano Masui, Yoshiharu Matahira, Mari Shibata, Hisashi Ashida, and Kenji Yamamoto Web Release Date: Thu, 24 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm8000967 Source: Journal of Medicinal Chemistry | 24 Jul 2008 | 6:00 am CEST

Identification of 4-Aminopyrazolylpyrimidines as Potent Inhibitors of Trk Kinases Tao Wang, Michelle L. Lamb, David A. Scott, Haixia Wang, Michael H. Block, Paul D. Lyne, John W. Lee, Audrey M. Davies, Hai-Jun Zhang, Yanyi Zhu, Fei Gu, Yongxin Han, Bin Wang, Peter J. Mohr, Robert J. Kaus, John A. Josey, Ethan Hoffmann, Ken Thress, Terry MacIntyre, Haiyun Wang, Charles A. Omer, and Dingwei Yu Web Release Date: Wed, 23 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800343j Source: Journal of Medicinal Chemistry | 23 Jul 2008 | 6:00 am CEST

False Positives in a Reporter Gene Assay: Identification and Synthesis of Substituted N-Pyridin-2-ylbenzamides as Competitive Inhibitors of Firefly Luciferase Laura H. Heitman, Jacobus P. D. van Veldhoven, Annelien M. Zweemer, Kai Ye, Johannes Brussee, and Adriaan P. IJzerman Web Release Date: Wed, 23 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm8004509 Source: Journal of Medicinal Chemistry | 23 Jul 2008 | 6:00 am CEST

Novel Quinolinonyl Diketo Acid Derivatives as HIV-1 Integrase Inhibitors: Design, Synthesis, and Biological Activities Roberto Di Santo, Roberta Costi, Alessandra Roux, Gaetano Miele, Giuliana Cuzzucoli Crucitti, Alberto Iacovo, Federica Rosi, Antonio Lavecchia, Luciana Marinelli, Carmen Di Giovanni, Ettore Novellino, Lucia Palmisano, Mauro Andreotti, Roberta Amici, Clementina Maria Galluzzo, Lucia Nencioni, Anna Teresa Palamara, Yves Pommier, and Christophe Marchand Web Release Date: Wed, 23 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm8001422 Source: Journal of Medicinal Chemistry | 23 Jul 2008 | 6:00 am CEST

Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 Inhibitors Tero Huhtiniemi, Tiina Suuronen, Valtteri M. Rinne, Carsten Wittekindt, Maija Lahtela-Kakkonen, Elina Jarho, Erik A. A. Wallén, Antero Salminen, Antti Poso, and Jukka Leppänen Web Release Date: Tue, 22 Jul 2008 00:00:00 EDT (Letter) DOI: 10.1021/jm800639h Source: Journal of Medicinal Chemistry | 22 Jul 2008 | 6:00 am CEST

Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6 Alan P. Kozikowski, Subhasish Tapadar, Doris N. Luchini, Ki Hwan Kim, and Daniel D. Billadeau Web Release Date: Tue, 22 Jul 2008 00:00:00 EDT (Letter) DOI: 10.1021/jm8002894 Source: Journal of Medicinal Chemistry | 22 Jul 2008 | 6:00 am CEST

Novel Analogues of Istaroxime, a Potent Inhibitor of Na+,K+-ATPase: Synthesis and Structure−Activity Relationship Mauro Gobbini, Silvia Armaroli, Leonardo Banfi, Alessandra Benicchio, Giulio Carzana, Giorgio Fedrizzi, Patrizia Ferrari, Giuseppe Giacalone, Michele Giubileo, Giuseppe Marazzi, Rosella Micheletti, Barbara Moro, Marco Pozzi, Piero Enrico Scotti, Marco Torri, and Alberto Cerri Web Release Date: Sat, 19 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800257s Source: Journal of Medicinal Chemistry | 19 Jul 2008 | 6:00 am CEST

Novel 4-Aminoquinolines Active against Chloroquine-Resistant and Sensitive P. falciparum Strains that also Inhibit Botulinum Serotype A Bogdan A. Šolaja, Dejan Opsenica, Kirsten S. Smith, Wilbur K. Milhous, Nataša Terzić, Igor Opsenica, James C. Burnett, Jon Nuss, Rick Gussio, and Sina Bavari Web Release Date: Sat, 19 Jul 2008 00:00:00 EDT (Letter) DOI: 10.1021/jm800737y Source: Journal of Medicinal Chemistry | 19 Jul 2008 | 6:00 am CEST

Synthesis and Evaluation of Technetium-99m- and Rhenium-Labeled Inhibitors of the Prostate-Specific Membrane Antigen (PSMA) Sangeeta R. Banerjee, Catherine A. Foss, Mark Castanares, Ronnie C. Mease, Youngjoo Byun, James J. Fox, John Hilton, Shawn E. Lupold, Alan P. Kozikowski, and Martin G. Pomper Web Release Date: Sat, 19 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800111u Source: Journal of Medicinal Chemistry | 19 Jul 2008 | 6:00 am CEST

(9S)-9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a Selective and Orally Active Neuropeptide Y Y5 Receptor Antagonist Nagaaki Sato, Makoto Jitsuoka, Takunobu Shibata, Tomoko Hirohashi, Katsumasa Nonoshita, Minoru Moriya, Yuji Haga, Aya Sakuraba, Makoto Ando, Tomoyuki Ohe, Hisashi Iwaasa, Akira Gomori, Akane Ishihara, Akio Kanatani, and Takehiro Fukami Web Release Date: Sat, 19 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm8003587 Source: Journal of Medicinal Chemistry | 19 Jul 2008 | 6:00 am CEST

2-Amino-6-furan-2-yl-4-substituted Nicotinonitriles as A2A Adenosine Receptor Antagonists Monica Mantri, Olivier de Graaf, Jacobus van Veldhoven, Anikó Göblyös, Jacobien K. von Frijtag Drabbe Künzel, Thea Mulder-Krieger, Regina Link, Henk de Vries, Margot W. Beukers, Johannes Brussee, and Adriaan P. IJzerman Web Release Date: Sat, 19 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm701594y Source: Journal of Medicinal Chemistry | 19 Jul 2008 | 6:00 am CEST

Ethyl 8-Fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as Novel, Highly Potent, and Safe Antianxiety Agent Maurizio Anzini, Carlo Braile, Salvatore Valenti, Andrea Cappelli, Salvatore Vomero, Luciana Marinelli, Vittorio Limongelli, Ettore Novellino, Laura Betti, Gino Giannaccini, Antonio Lucacchini, Carla Ghelardini, Monica Norcini, Francesco Makovec, Gianluca Giorgi, and R. Ian Fryer Web Release Date: Sat, 19 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm8002944 Source: Journal of Medicinal Chemistry | 19 Jul 2008 | 6:00 am CEST

Structure−Antitussive Activity Relationships of Naltrindole Derivatives. Identification of Novel and Potent Antitussive Agents Satoshi Sakami, Masayuki Maeda, Koji Kawai, Takumi Aoki, Kuniaki Kawamura, Hideaki Fujii, Ko Hasebe, Mayumi Nakajima, Takashi Endo, Shinya Ueno, Tsuyoshi Ito, Junzo Kamei, and Hiroshi Nagase Web Release Date: Sat, 19 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm701440h Source: Journal of Medicinal Chemistry | 19 Jul 2008 | 6:00 am CEST

A Pentacyclic Aurora Kinase Inhibitor (AKI-001) with High in Vivo Potency and Oral Bioavailability Thomas E. Rawson, Matthias Rüth, Elizabeth Blackwood, Dan Burdick, Laura Corson, Jenna Dotson, Jason Drummond, Carter Fields, Guy J. Georges, Bernhard Goller, Jason Halladay, Thomas Hunsaker, Tracy Kleinheinz, Hans-Willi Krell, Jun Li, Jun Liang, Anja Limberg, Angela McNutt, John Moffat, Gail Phillips, Yingqing Ran, Brian Safina, Mark Ultsch, Leslie Walker, Christian Wiesmann, Birong Zhang, Aihe Zhou, Bing-Yan Zhu, Petra Rüger, and Andrea G. Cochran Web Release Date: Thu, 17 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800052b Source: Journal of Medicinal Chemistry | 17 Jul 2008 | 6:00 am CEST

Structure-Based Development of Novel Adenylyl Cyclase Inhibitors Christine Schlicker, Annika Rauch, Ken C. Hess, Barbara Kachholz, Lonny R. Levin, Jochen Buck, and Clemens Steegborn Web Release Date: Thu, 17 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800481q Source: Journal of Medicinal Chemistry | 17 Jul 2008 | 6:00 am CEST

Substituted 6-Phenyl-2-naphthols. Potent and Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Design, Synthesis, Biological Evaluation, and Pharmacokinetics Sandrine Marchais-Oberwinkler, Patricia Kruchten, Martin Frotscher, Erika Ziegler, Alexander Neugebauer, Umadevi Bhoga, Emmanuel Bey, Ursula Müller-Vieira, Josef Messinger, Hubert Thole, and Rolf W. Hartmann Web Release Date: Thu, 17 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800367k Source: Journal of Medicinal Chemistry | 17 Jul 2008 | 6:00 am CEST

Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design Shijun Zhong, Xi Chen, Xiao Zhu, Barbara Dziegielewska, Kurtis E. Bachman, Tom Ellenberger, Jeff D. Ballin, Gerald M. Wilson, Alan E. Tomkinson, and Alexander D. MacKerell Jr. Web Release Date: Thu, 17 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm8001668 Source: Journal of Medicinal Chemistry | 17 Jul 2008 | 6:00 am CEST

Design, Synthesis, and Biological Evaluation of 14-Substituted Aromathecins as Topoisomerase I Inhibitors Maris A. Cinelli, Andrew Morrell, Thomas S. Dexheimer, Evan S. Scher, Yves Pommier, and Mark Cushman Web Release Date: Thu, 17 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800259e Source: Journal of Medicinal Chemistry | 17 Jul 2008 | 6:00 am CEST

5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a Series of Anti-HIV-1 Agents of the Dihydro-alkoxy-benzyl-oxopyrimidine Family with Peculiar Structure−Activity Relationship Profile Maxim B. Nawrozkij, Dante Rotili, Domenico Tarantino, Giorgia Botta, Alexandre S. Eremiychuk, Ira Musmuca, Rino Ragno, Alberta Samuele, Samantha Zanoli, Mercedes Armand-Ugón, Imma Clotet-Codina, Ivan A. Novakov, Boris S. Orlinson, Giovanni Maga, José A. Esté, Marino Artico, and Antonello Mai Web Release Date: Thu, 17 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800340w Source: Journal of Medicinal Chemistry | 17 Jul 2008 | 6:00 am CEST

Slow Self-Activation Enhances The Potency of Viridin Prodrugs Joseph Blois, Hushan Yuan, Adam Smith, Michael E. Pacold, Ralph Weissleder, Lewis C. Cantley, and Lee Josephson Web Release Date: Thu, 17 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800374f Source: Journal of Medicinal Chemistry | 17 Jul 2008 | 6:00 am CEST

Book Review of Biosimulation in Drug Development Kevin D. Hall Web Release Date: Thu, 17 Jul 2008 00:00:00 EDT (Book Review) DOI: 10.1021/jm800678c Source: Journal of Medicinal Chemistry | 17 Jul 2008 | 6:00 am CEST

Selective Nucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2) Inhibitors: Nucleotide Mimetics Derived from Uridine-5′-carboxamide Andreas Brunschweiger, Jamshed Iqbal, Frank Umbach, Anja B. Scheiff, Mercedes N. Munkonda, Jean Sévigny, Aileen F. Knowles, and Christa E Müller Web Release Date: Thu, 17 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800175e Source: Journal of Medicinal Chemistry | 17 Jul 2008 | 6:00 am CEST

Book Review of Drug Metabolism. Chemical and Enzymatic Aspects Manfred E. Wolff Web Release Date: Thu, 17 Jul 2008 00:00:00 EDT (Book Review) DOI: 10.1021/jm800706c Source: Journal of Medicinal Chemistry | 17 Jul 2008 | 6:00 am CEST

Optimization of the Central Heterocycle of α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Joie Garfunkle, Cyrine Ezzili, Thomas J. Rayl, Dustin G. Hochstatter, Inkyu Hwang, and Dale L. Boger Web Release Date: Wed, 16 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800136b Source: Journal of Medicinal Chemistry | 16 Jul 2008 | 6:00 am CEST

Influence of Conformational Flexibility on Complexation-Induced Changes in Chemical Shift in a Neocarzinostatin Protein−Ligand Complex Marina Cioffi, Christopher A. Hunter, and Martin J. Packer Web Release Date: Tue, 15 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800075r Source: Journal of Medicinal Chemistry | 15 Jul 2008 | 6:00 am CEST

High Affinity Conformationally Constrained Nociceptin/Orphanin FQ(1−13) Amide Analogues Laksana Charoenchai, Hongyan Wang, Jia Bei Wang, and Jane V. Aldrich Web Release Date: Tue, 15 Jul 2008 00:00:00 EDT (Letter) DOI: 10.1021/jm800394v Source: Journal of Medicinal Chemistry | 15 Jul 2008 | 6:00 am CEST

Targeting the Lysosome: Fluorescent Iron(III) Chelators To Selectively Monitor Endosomal/Lysosomal Labile Iron Pools Sarah Fakih, Maria Podinovskaia, Xiaole Kong, Helen L. Collins, Ulrich E. Schaible, and Robert C. Hider Web Release Date: Tue, 15 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm8001247 Source: Journal of Medicinal Chemistry | 15 Jul 2008 | 6:00 am CEST

Novel Terphenyls and 3,5-Diaryl Isoxazole Derivatives Endowed with Growth Supporting and Antiapoptotic Properties Daniele Simoni, Riccardo Rondanin, Riccardo Baruchello, Michele Rizzi, Giuseppina Grisolia, Marco Eleopra, Stefania Grimaudo, Antonietta Di Cristina, Maria Rosaria Pipitone, Maria Rita Bongiorno, Mario Aricò, Francesco Paolo Invidiata, and Manlio Tolomeo Web Release Date: Sat, 12 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800388m Source: Journal of Medicinal Chemistry | 12 Jul 2008 | 6:00 am CEST

Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor Philip A. Harris, Amogh Boloor, Mui Cheung, Rakesh Kumar, Renae M. Crosby, Ronda G. Davis-Ward, Andrea H. Epperly, Kevin W. Hinkle, Robert N. Hunter III, Jennifer H. Johnson, Victoria B. Knick, Christopher P. Laudeman, Deirdre K. Luttrell, Robert A. Mook, Robert T. Nolte, Sharon K. Rudolph, Jerzy R. Szewczyk, Anne T. Truesdale, James M. Veal, Liping Wang, and Jeffrey A. Stafford Web Release Date: Sat, 12 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800566m Source: Journal of Medicinal Chemistry | 12 Jul 2008 | 6:00 am CEST

Novel Indoline-Based Acyl-CoA:Cholesterol Acyltransferase Inhibitor with Antiperoxidative Activity: Improvement of Physicochemical Properties and Biological Activities by Introduction of Carboxylic Acid Kenji Takahashi, Masayasu Kasai, Masaru Ohta, Yoshimichi Shoji, Kazuyoshi Kunishiro, Mamoru Kanda, Kazuyoshi Kurahashi, and Hiroaki Shirahase Web Release Date: Sat, 12 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800248r Source: Journal of Medicinal Chemistry | 12 Jul 2008 | 6:00 am CEST

Selectivity Determinants of Inhibitor Binding to Human 20α-Hydroxysteroid Dehydrogenase: Crystal Structure of the Enzyme in Ternary Complex with Coenzyme and the Potent Inhibitor 3,5-Dichlorosalicylic Acid Urmi Dhagat, Satoshi Endo, Rie Sumii, Akira Hara, and Ossama El-Kabbani Web Release Date: Sat, 12 Jul 2008 00:00:00 EDT (Brief Article) DOI: 10.1021/jm8003575 Source: Journal of Medicinal Chemistry | 12 Jul 2008 | 6:00 am CEST

Chemical Proteomics-Based Drug Design: Target and Antitarget Fishing with a Catechol−Rhodanine Privileged Scaffold for NAD(P)(H) Binding Proteins Xia Ge, Bassam Wakim, and Daniel S. Sem Web Release Date: Fri, 11 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm8002284 Source: Journal of Medicinal Chemistry | 11 Jul 2008 | 6:00 am CEST

Methyl (11aS)-1,2,3,5,11,11a-Hexahydro-3,3-dimethyl-1-oxo-6H-imidazo-[3′,4′:1,2]pyridin[3,4-b]indol-2-Substituted Acetates: Synthesis and Three-Dimensional Quantitative Structure−Activity Relationship Investigation as a Class of Novel Vasodilators Jiawang Liu, Ming Zhao, Guohui Cui, Xiaoyi Zhang, Jun Wang, and Shiqi Peng Web Release Date: Fri, 11 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800249j Source: Journal of Medicinal Chemistry | 11 Jul 2008 | 6:00 am CEST

Structure of Daidzin, a Naturally Occurring Anti-Alcohol-Addiction Agent, in Complex with Human Mitochondrial Aldehyde Dehydrogenase Edward D. Lowe, Guang-Yao Gao, Louise N. Johnson, and Wing Ming Keung Web Release Date: Thu, 10 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800488j Source: Journal of Medicinal Chemistry | 10 Jul 2008 | 6:00 am CEST

Naturally Occurring Homoisoflavonoids Function as Potent Protein Tyrosine Kinase Inhibitors by c-Src-Based High-Throughput Screening Li-Gen Lin, Hua Xie, Hong-Lin Li, Lin-Jiang Tong, Chun-Ping Tang, Chang-Qiang Ke, Qun-Fang Liu, Li-Ping Lin, Mei-Yu Geng, Hualiang Jiang, Wei-Min Zhao, Jian Ding, and Yang Ye Web Release Date: Wed, 9 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm701501x Source: Journal of Medicinal Chemistry | 9 Jul 2008 | 6:00 am CEST

The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore Hai Xu, James W. Fairman, Sanath R. Wijerathna, Nathan R. Kreischer, John LaMacchia, Elizabeth Helmbrecht, Barry S. Cooperman, and Chris Dealwis Web Release Date: Wed, 9 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800350u Source: Journal of Medicinal Chemistry | 9 Jul 2008 | 6:00 am CEST

Asymmetric Synthesis of 2,3-Dihydro-2-arylquinazolin-4-ones: Methodology and Application to a Potent Fluorescent Tubulin Inhibitor with Anticancer Activity Gary M. Chinigo, Mikell Paige, Scott Grindrod, Ernest Hamel, Sivanesan Dakshanamurthy, Maksymilian Chruszcz, Wladek Minor, and Milton L. Brown Web Release Date: Wed, 9 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800271c Source: Journal of Medicinal Chemistry | 9 Jul 2008 | 6:00 am CEST

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies Hiroyuki Sato, Antonio Macchiarulo, Charles Thomas, Antimo Gioiello, Mizuho Une, Alan F. Hofmann, Régis Saladin, Kristina Schoonjans, Roberto Pellicciari, and Johan Auwerx Web Release Date: Wed, 9 Jul 2008 00:00:00 EDT (Addition/Correction) DOI: 10.1021/jm8007135 Source: Journal of Medicinal Chemistry | 9 Jul 2008 | 6:00 am CEST

Design, Synthesis, and Biological Evaluation of Antiviral Agents Targeting Flavivirus Envelope Proteins Ze Li, Mansoora Khaliq, Zhigang Zhou, Carol Beth Post, Richard J. Kuhn, and Mark Cushman Web Release Date: Wed, 9 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800412d Source: Journal of Medicinal Chemistry | 9 Jul 2008 | 6:00 am CEST

Book Review of Medicinal Chemistry. An Introduction. Second Edition Kennerly S. Patrick Web Release Date: Wed, 9 Jul 2008 00:00:00 EDT (Book Review) DOI: 10.1021/jm800676e Source: Journal of Medicinal Chemistry | 9 Jul 2008 | 6:00 am CEST

Highly Specific and Broadly Potent Inhibitors of Mammalian Secreted Phospholipases A2 Rob C. Oslund, Nathan Cermak, and Michael H. Gelb Web Release Date: Tue, 8 Jul 2008 00:00:00 EDT (Brief Article) DOI: 10.1021/jm800422v Source: Journal of Medicinal Chemistry | 8 Jul 2008 | 6:00 am CEST

Synthesis and Anti-HIV Activity of 4′-Substituted 4′-Thiothymidines: A New Entry Based on Nucleophilic Substitution of the 4′-Acetoxy Group Kazuhiro Haraguchi, Hisashi Shimada, Hiromichi Tanaka, Takayuki Hamasaki, Masanori Baba, Elizabeth A. Gullen, Ginger E. Dutschman, and Yung-Chi Cheng Web Release Date: Tue, 8 Jul 2008 00:00:00 EDT (Addition/Correction) DOI: 10.1021/jm8006036 Source: Journal of Medicinal Chemistry | 8 Jul 2008 | 6:00 am CEST

Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush Michela Rosini, Elena Simoni, Manuela Bartolini, Andrea Cavalli, Luisa Ceccarini, Nicoleta Pascu, David W. McClymont, Andrea Tarozzi, Maria L. Bolognesi, Anna Minarini, Vincenzo Tumiatti, Vincenza Andrisano, Ian R. Mellor, and Carlo Melchiorre Web Release Date: Tue, 8 Jul 2008 00:00:00 EDT (Letter) DOI: 10.1021/jm800577j Source: Journal of Medicinal Chemistry | 8 Jul 2008 | 6:00 am CEST

Lipid-Conjugated Oligonucleotides via “Click Chemistry” Efficiently Inhibit Hepatitis C Virus Translation Guilhem Godeau, Cathy Staedel, and Philippe Barthélémy Web Release Date: Tue, 8 Jul 2008 00:00:00 EDT (Letter) DOI: 10.1021/jm800518u Source: Journal of Medicinal Chemistry | 8 Jul 2008 | 6:00 am CEST

The Effect of 5-Alkyl Modification on the Biological Activity of Pyrrolo[2,3-d]pyrimidine Containing Classical and Nonclassical Antifolates as Inhibitors of Dihydrofolate Reductase and as Antitumor and/or Antiopportunistic Infection Agents1a–1e Aleem Gangjee, Hiteshkumar D. Jain, Sherry F. Queener, and Roy L. Kisliuk Web Release Date: Tue, 8 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800244v Source: Journal of Medicinal Chemistry | 8 Jul 2008 | 6:00 am CEST

Gold(I)-Mediated Inhibition of Protein Tyrosine Phosphatases: A Detailed in Vitro and Cellular Study Divya Krishnamurthy, Mark R. Karver, Edoardo Fiorillo, Valeria Orrú, Stephanie M. Stanford, Nunzio Bottini, and Amy M. Barrios Web Release Date: Tue, 8 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800101w Source: Journal of Medicinal Chemistry | 8 Jul 2008 | 6:00 am CEST

Discovery of (−)-7-Methyl-2-exo-[3′-(6-[18F]fluoropyridin-2-yl)-5′-pyridinyl]-7-azabicyclo[2.2.1]heptane, a Radiolabeled Antagonist for Cerebral Nicotinic Acetylcholine Receptor (α4β2-nAChR) with Optimal Positron Emission Tomography Imaging Properties Yongjun Gao, Hiroto Kuwabara, Charles E. Spivak, Yingxian Xiao, Kenneth Kellar, Hayden T. Ravert, Anil Kumar, Mohab Alexander, John Hilton, Dean F. Wong, Robert F. Dannals, and Andrew G. Horti Web Release Date: Tue, 8 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800323d Source: Journal of Medicinal Chemistry | 8 Jul 2008 | 6:00 am CEST

Central Metal Determines Pharmacokinetics of Chlorophyll-Derived Xenobiotics Małgorzata Szczygieł, Krystyna Urbańska, Patrycja Jurecka, Iwona Stawoska, Grażyna Stochel, and Leszek Fiedor Web Release Date: Tue, 8 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm7016368 Source: Journal of Medicinal Chemistry | 8 Jul 2008 | 6:00 am CEST

Synthesis, Biological Evaluation, and Enzyme Docking Simulations of 1,5-Diarylpyrrole-3-Alkoxyethyl Ethers as Selective Cyclooxygenase-2 Inhibitors Endowed with Anti-inflammatory and Antinociceptive Activity Maurizio Anzini, Michele Rovini, Andrea Cappelli, Salvatore Vomero, Fabrizio Manetti, Maurizio Botta, Lidia Sautebin, Antonietta Rossi, Carlo Pergola, Carla Ghelardini, Monica Norcini, Antonio Giordani, Francesco Makovec, Paola Anzellotti, Paola Patrignani, and Mariangela Biava Web Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800084s Source: Journal of Medicinal Chemistry | 4 Jul 2008 | 6:00 am CEST

Inorganic Polyhedral Metallacarborane Inhibitors of HIV Protease: A New Approach to Overcoming Antiviral Resistance Milan Kožíšek, Petr Cígler, Martin Lepšík, Jindřich Fanfrlík, Pavlína Řezáčová, Jiří Brynda, Jana Pokorná, Jaromír Plešek, Bohumír Grüner, Klára Grantz Šašková, Jana Václavíková, Vladimír Král, and Jan Konvalinka Web Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Brief Article) DOI: 10.1021/jm8002334 Source: Journal of Medicinal Chemistry | 4 Jul 2008 | 6:00 am CEST

Antitumor Activity of Bis-indole Derivatives1 Aldo Andreani, Silvia Burnelli, Massimiliano Granaiola, Alberto Leoni, Alessandra Locatelli, Rita Morigi, Mirella Rambaldi, Lucilla Varoli, Laura Landi, Cecilia Prata, Michael V. Berridge, Carole Grasso, Heinz-Herbert Fiebig, Gerhard Kelter, Angelika M. Burger, and Mark W. Kunkel Web Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800194k Source: Journal of Medicinal Chemistry | 4 Jul 2008 | 6:00 am CEST

Design, Synthesis, and Antihepatocellular Carcinoma Activity of Nitric Oxide Releasing Derivatives of Oleanolic Acid Li Chen, Yihua Zhang, Xiangwen Kong, Edward Lan, Zhangjian Huang, Sixun Peng, Daniel L. Kaufman, and Jide Tian Web Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Brief Article) DOI: 10.1021/jm800167u Source: Journal of Medicinal Chemistry | 4 Jul 2008 | 6:00 am CEST

Synthesis, Structure−Activity Relationships, and Biological Profiles of a Quinazolinone Class of Histamine H3 Receptor Inverse Agonists Tsuyoshi Nagase, Takashi Mizutani, Shiho Ishikawa, Etsuko Sekino, Takahide Sasaki, Takashi Fujimura, Sayaka Ito, Yuko Mitobe, Yasuhisa Miyamoto, Ryo Yoshimoto, Takeshi Tanaka, Akane Ishihara, Norihiro Takenaga, Shigeru Tokita, Takehiro Fukami, and Nagaaki Sato Web Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm8003834 Source: Journal of Medicinal Chemistry | 4 Jul 2008 | 6:00 am CEST

Synthesis of New Arylpiperazinylalkylthiobenzimidazole, Benzothiazole, or Benzoxazole Derivatives as Potent and Selective 5-HT1A Serotonin Receptor Ligands Maria A. Siracusa, Loredana Salerno, Maria N. Modica, Valeria Pittalà, Giuseppe Romeo, Maria E. Amato, Mateusz Nowak, Andrzej J. Bojarski, Ilario Mereghetti, Alfredo Cagnotto, and Tiziana Mennini Web Release Date: Fri, 4 Jul 2008 00:00:00 EDT (Article) DOI: 10.1021/jm800176x Source: Journal of Medicinal Chemistry | 4 Jul 2008 | 6:00 am CEST

The Many Roles for Fluorine in Medicinal Chemistry William K. Hagmann Web Release Date: Sat, 21 Jun 2008 00:00:00 EDT (Perspective) DOI: 10.1021/jm800219f Source: Journal of Medicinal Chemistry | 21 Jun 2008 | 6:00 am CEST

null null Web Release Date: Wed, 21 Sep 2005 00:00:00 EDT (Editorial) DOI: 10.1021/jm058265h Source: Journal of Medicinal Chemistry | 21 Sep 2005 | 6:00 am CEST

null null Web Release Date: Wed, 12 May 2004 00:00:00 EDT (null) DOI: 10.1021/jm0400855 Source: Journal of Medicinal Chemistry | 12 May 2004 | 6:00 am CEST

In vitro aldose reductase inhibitory activity of some flavonyl-2,4-thiazolidinediones Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Design, synthesis and preliminary screening of novel 3-(2- N , N -dimethylaminoethylthio) indole derivatives as potential 5-HT 6 receptor ligands Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Butyrylcholinesterase, lipoxygenase inhibiting and antifungal alkaloids from isatis tinctoria Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Xanthine dehydrogenase processes retinol to retinoic acid in human mammary epithelial cells Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Effect of mesoionic 4-phenyl-5-(cinnamoyl)-1,3,4-thiadiazolium-2-phenylamine chloride derivative salts on the activities of the nitric oxide synthase and arginase of Leishmania amazonensis Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Synthesis and evaluation of N-substituted indole-3-carboxamide derivatives as inhibitors of lipid peroxidation and superoxide anion formation Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Microbial and xanthine dehydrogenase inhibitory activity of some flavones Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Design, synthesis, characterization, antibacterial and antifungal activities of a novel class of 5,7-diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino[3,4-d]-1,2,3-selenadiazoles Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Novel peptide-based pepsin inhibitors containing an epoxide group Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Brucella suis histidinol dehydrogenase: Synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Antimicrobial effect by extracts of rhizome of Alpinia officinarum Hance may relate to its inhibition of β-ketoacyl-ACP reductase Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Structural elucidation and biological significance of 2-hydroxy-1-naphthaldehyde derived sulfonamides and their first row d-transition metal chelates Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Some kinetic properties of polyphenol oxidase obtained from dill ( Anethum graveolens ) Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Urease inhibitor from Datisca cannabina linn Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Modulation of Anopheles gambiae Epsilon glutathione transferase activity by plant natural products in vitro Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

α-Chymotrypsin inhibition studies on the lignans from Vitex negundo Linn Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Renierol from marine sponge Haliclona.SP.: A natural inhibitor of xanthine oxidase with hypouricemic effects Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Some characteristics of Rabbit muscle phosphofructokinase-1 inhibition by ascorbate Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Investigation of the effects of some sulfonamide derivatives on the activities of glucose-6-phosphate dehydrogenase, 6-phospho gluconate dehydrogenase and glutathione reductase from human erythrocytes Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Prediction of caspase-3 inhibitory activity of 1,3-dioxo-4-methyl-2,3-dihydro-1h-pyrrolo[3,4-c] quinolines: QSAR study Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Synthesis and antimycobacterial activity of 4-[5-(substituted phenyl)-4, 5-dihydro-3-isoxazolyl]-2-methylphenols Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Quantitative structure-activity relationship study on affinity profile of a series of 1,8-naphthyridine antagonists toward bovine adenosine receptors Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Obituary - Professor Jörg Stürzebecher Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

Advances in assays of matrix metalloproteinases (MMPs) and their inhibitors Source: Journal of Enzyme Inhibition and Medicinal Chemistry: Articles recently published in |

A quantitative structure-activity r