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Auf dieser Seite beruecksichtige naturwissenschaftliche Journale:

Beilstein Journal of Organic Chemistry - published by The Beilstein-Institut -
... in cooperation with BioMed Central - is an Open Access, peer-reviewed online journal that will encompass all aspects of organic chemistry. Full research papers and preliminary communications (short reports) will be published in the journal.

The Journal of Organic Chemistry - published by The American Chemical Society -
Original contributions reporting novel, important findings of fundamental research in all branches of the theory and practice of organic and bioorganic chemistry.

Organic Letters - published by The American Chemical Society -
Brief reports of significant research concerning organic chemistry, including organic synthesis, organometallic, natural product, physical organic, bioorganic, and medicinal chemistry.

European Journal of Organic Chemistry - published by Wiley-Interscience -
... publishes Full Papers, Short Communications, and Microreviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry.

Aktuelle wissenschaftliche Fachartikel der genannten Journale:

Total Synthesis of Citrafungin A

Frederick Calo, Jeffery Richardson, and Anthony G. M. Barrett
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo801708q

Quelle: The Journal of Organic Chemistry | 4 Oct 2008 | 6:00 am CEST

Palladium- and Nickel-Catalyzed Cross-Couplings of Unsaturated Halides Bearing Relatively Acidic Protons with Organozinc Reagents

Georg Manolikakes, Carmen Muñoz Hernandez, Matthias A. Schade, Albrecht Metzger, and Paul Knochel
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo8015852

Quelle: The Journal of Organic Chemistry | 4 Oct 2008 | 6:00 am CEST

Highly Stereoselective Synthesis of cis-Alkenyl Pinacolboronates and Potassium cis-Alkenyltrifluoroborates via a Hydroboration/Protodeboronation Approach

Gary A. Molander and Noel M. Ellis
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Addition/Correction) DOI: 10.1021/jo8020852

Quelle: The Journal of Organic Chemistry | 4 Oct 2008 | 6:00 am CEST

Asymmetric Synthesis of β-Nitro Ketones via Michael Addition of Lithiated α-Amino Nitriles to Nitroalkenes

Dieter Enders, Dominik Förster, Gerhard Raabe, and Jan W. Bats
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo8017318

Quelle: The Journal of Organic Chemistry | 4 Oct 2008 | 6:00 am CEST

Cascade Synthesis of 3-Quinolinecarboxylic Ester via Benzylation/ Propargylation−Cyclization

Jinmin Fan, Changfeng Wan, Gaojun Sun, and Zhiyong Wang
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Note) DOI: 10.1021/jo8017654

Quelle: The Journal of Organic Chemistry | 4 Oct 2008 | 6:00 am CEST

Theoretical Prediction of a Perepoxide Intermediate for the Reaction of Singlet Oxygen with trans-Cyclooctene Contrasts with the Two-Step No-Intermediate Ene Reaction for Acyclic Alkenes

Andrew G. Leach, K. N. Houk, and Christopher S. Foote
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo8016154

Quelle: The Journal of Organic Chemistry | 4 Oct 2008 | 6:00 am CEST

Short Enantioselective Syntheses of trans-5-Alkylprolines from New Functionalized Amino Alcohols

Jeanne Alladoum, Sylvain Roland, Emmanuel Vrancken, Pierre Mangeney, and Catherine Kadouri-Puchot
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Note) DOI: 10.1021/jo8014243

Quelle: The Journal of Organic Chemistry | 4 Oct 2008 | 6:00 am CEST

Sintokamides A to E, Chlorinated Peptides from the Sponge Dysidea sp. that Inhibit Transactivation of the N-Terminus of the Androgen Receptor in Prostate Cancer Cells

Marianne D. Sadar, David E. Williams, Nasrin R. Mawji, Brian O. Patrick, Thamrin Wikanta, Ekowati Chasanah, Hari Eko Irianto, Rob Van Soest, and Raymond J. Andersen
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol802021w

Quelle: Organic Letters | 4 Oct 2008 | 6:00 am CEST

Iridium-Catalyzed Asymmetric Ring-Opening Reactions of N-Boc-azabenzonorbornadiene with Secondary Amine Nucleophiles

Dingqiao Yang, Yuhua Long, Huan Wang, and Zhenming Zhang
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801768e

Quelle: Organic Letters | 4 Oct 2008 | 6:00 am CEST

Internal Dynamics and Optical Rotations Predicted for Oh- and O-Symmetric Cubanes

David A. Hrovat, Christine M. Isborn, Bart Kahr, and Weston Thatcher Borden
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801762r

Quelle: Organic Letters | 4 Oct 2008 | 6:00 am CEST

Domino Transformation of D-Glucal to Racemic α-Substituted α-Hydroxymethyl Furfuryl Derivatives

Debaraj Mukherjee, Syed Khalid Yousuf, and Subhash Chandra Taneja
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801917n

Quelle: Organic Letters | 4 Oct 2008 | 6:00 am CEST

Hydrazide as a New Hydrogen-Bonding Motif for Resorcin[4]arene-Based Molecular Capsules

Yeon Sil Park and Kyungsoo Paek
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801945p

Quelle: Organic Letters | 4 Oct 2008 | 6:00 am CEST

Gold-Catalyzed Hydrative Carbocyclization of 1,5- and 1,6-Diyn-3-ones via an Oxygen Transfer Process

Jhih-Meng Tang, Ting-An Liu, and Rai-Shung Liu
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo801753g

Quelle: The Journal of Organic Chemistry | 4 Oct 2008 | 6:00 am CEST

Synthesis of Substituted Naphthalenes via a Catalytic Ring-Expansion Rearrangement

Adam C. Glass, Benjamin B. Morris, Lev N. Zakharov, and Shih-Yuan Liu
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol8019617

Quelle: Organic Letters | 4 Oct 2008 | 6:00 am CEST

Organocatalytic Michael Addition of Aldehydes to Vinyl Sulfones: Enantioselective α-Alkylations of Aldehydes and Their Derivatives

Qiang Zhu and Yixin Lu
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol8019296

Quelle: Organic Letters | 4 Oct 2008 | 6:00 am CEST

One-Pot Formation of Allylic Chlorides from Carbonyl Derivatives

Matthew J. Fuchter and Jean-Noël Levy
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol802026u

Quelle: Organic Letters | 4 Oct 2008 | 6:00 am CEST

First Cross-Coupling Reaction of Potassium Aryltrifluoroborates with Organic Chlorides in Aqueous Media Catalyzed by an Oxime-Derived Palladacycle

Emilio Alacid and Carmen Nájera
Web Release Date: Sat, 4 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol802024j

Quelle: Organic Letters | 4 Oct 2008 | 6:00 am CEST

Tandem Aziridination/Rearrangement Reaction of Allylic Alcohols: An Efficient Approach to 2-Quaternary Mannich Bases

En Zhang, Yong-Qiang Tu, Chun-An Fan, Xiong Zhao, Yi-Jun Jiang, and Shu-Yu Zhang
Web Release Date: Fri, 3 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol802005n

Quelle: Organic Letters | 3 Oct 2008 | 6:00 am CEST

Enantioselective Organocatalytic Approach to α-Methylene-δ-lactones and δ-Lactams

Łukasz Albrecht, Bo Richter, Henryk Krawczyk, and Karl Anker Jørgensen
Web Release Date: Fri, 3 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo801582t

Quelle: The Journal of Organic Chemistry | 3 Oct 2008 | 6:00 am CEST

Ratiometric Sensing of Hg2+ Based on the Calix[4]arene of Partial Cone Conformation Possessing a Dansyl Moiety

Abhimanew Dhir, Vandana Bhalla, and Manoj Kumar
Web Release Date: Fri, 3 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801984y

Quelle: Organic Letters | 3 Oct 2008 | 6:00 am CEST

Iodocyclization of Ethoxyethyl Ethers to Alkynes: A Broadly Applicable Synthesis of 3-Iodobenzo[b]furans

Takashi Okitsu, Daisuke Nakazawa, Rie Taniguchi, and Akimori Wada
Web Release Date: Fri, 3 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol8020463

Quelle: Organic Letters | 3 Oct 2008 | 6:00 am CEST

The Journal of Organic Chemistry

The Journal of Organic Chemistry, Volume 73 Issue 19 (October 3, 2008) is now available

Quelle: The Journal of Organic Chemistry | 3 Oct 2008 | 6:00 am CEST

An Efficient Synthesis of 2,6-Disubstituted Benzobisoxazoles: New Building Blocks for Organic Semiconductors

Jared F. Mike, Andrew J. Makowski, and Malika Jeffries-EL
Web Release Date: Fri, 3 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol802011y

Quelle: Organic Letters | 3 Oct 2008 | 6:00 am CEST

L-Selectride-Mediated Highly Diastereoselective Asymmetric Reductive Aldol Reaction: Access to an Important Subunit for Bioactive Molecules

Arun K. Ghosh, Jorden Kass, David D. Anderson, Xiaoming Xu, and Christine Marian
Web Release Date: Fri, 3 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801971t

Quelle: Organic Letters | 3 Oct 2008 | 6:00 am CEST

Et3N-Induced Demethylation−Annulation of 3-Alkynyl-4-methoxy-2-pyridones and Structurally Related Compounds in the Synthesis of Furan-Fused Heterocycles

David Conreaux, Sébastien Belot, Philippe Desbordes, Nuno Monteiro, and Geneviève Balme
Web Release Date: Fri, 3 Oct 2008 00:00:00 EDT (Note) DOI: 10.1021/jo8014038

Quelle: The Journal of Organic Chemistry | 3 Oct 2008 | 6:00 am CEST

Novel and Rapid Palladium-Assisted 6π Electrocyclic Reaction Affording 9,10-Dihydrophenanthrene and Its Analogues

Rathin Jana, Indranil Chatterjee, Shubhankar Samanta, and Jayanta K. Ray
Web Release Date: Thu, 2 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801882t

Quelle: Organic Letters | 2 Oct 2008 | 6:00 am CEST

Palladium-Catalyzed Conjugate Allylation Reactions of α,β-Unsaturated N-Acylpyrroles

Michael B. Shaghafi, Benjamin L. Kohn, and Elizabeth R. Jarvo
Web Release Date: Thu, 2 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801830h

Quelle: Organic Letters | 2 Oct 2008 | 6:00 am CEST

Organic Letters

Organic Letters, Volume 10 Issue 19 (October 2, 2008) is now available

Quelle: Organic Letters | 2 Oct 2008 | 6:00 am CEST

Synthesis of Covalently Linked Unsymmetrical Porphyrin Pentads Containing Three Different Porphyrin Subunits

Smita Rai and Mangalampalli Ravikanth
Web Release Date: Thu, 2 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo801455w

Quelle: The Journal of Organic Chemistry | 2 Oct 2008 | 6:00 am CEST

Catalytic Chain-Breaking Pyridinol Antioxidants

Sangit Kumar, Henrik Johansson, Takahiro Kanda, Lars Engman, Thomas Müller, Mats Jonsson, Gian Franco Pedulli, Silvia Petrucci, and Luca Valgimigli
Web Release Date: Thu, 2 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801983n

Quelle: Organic Letters | 2 Oct 2008 | 6:00 am CEST

A Rhodamine−Cyclen Conjugate as a Highly Sensitive and Selective Fluorescent Chemosensor for Hg(II)

Yasuhiro Shiraishi, Shigehiro Sumiya, Yoshiko Kohno, and Takayuki Hirai
Web Release Date: Thu, 2 Oct 2008 00:00:00 EDT (Note) DOI: 10.1021/jo8012447

Quelle: The Journal of Organic Chemistry | 2 Oct 2008 | 6:00 am CEST

Regioselective Acylation of Nucleosides Catalyzed by Candida Antarctica Lipase B: Enzyme Substrate Recognition

The substrate recognition of Candida antarctica lipase B (CAL-B) in the acylation of nucleosides was revealed through rational substrate engineering for the first time. CAL-B displayed lower activities and excellent 5[prime]-regioselectivities (94 to >99 %) in the acylation of ribonucleosides 1f-1j as compared to those in the acylation of 2[prime]-deoxynucleosides 1a-1e. The excellent regioselectivities might be attributed to the favorable steric hindrance of the 2[prime]-hydroxy group present in ribonucleosides 1f-1j, which destabilizes the conformation of the 3[prime]-acylation transition state in the acylation of 1f-1j and thus reduces the amount of the minor regioisomer. The study of the acyl chain-length specificity showed that CAL-B was more specific toward short-chain fatty acid vinyl esters, especially vinyl butyrate. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Quelle: European Journal of Organic Chemistry | 1 Oct 2008 | 10:52 am CEST

Preparation of the First Bench-Stable Phenyl Selenolate: an Interesting "On Water" Nucleophilic Reagent

In this communication we report the synthesis and the characterization of the first solid and air-stable selenolates, starting from commercially available phenylselenenyl halides and elemental zinc. These reagents were efficiently employed in the ring opening of epoxides as well as in other nucleophilic substitution and addition reactions showing an unexpected rate acceleration in water suspension at room temperature. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Quelle: European Journal of Organic Chemistry | 1 Oct 2008 | 10:52 am CEST

Palladium-Catalyzed Amination and Sulfonylation of 5-Bromo-3-[2-(diethylamino)ethoxy]indoles to Potential 5-HT6 Receptor Ligands

A general and efficient palladium-catalyzed amination of 5-bromo-3-[2-(diethylamino)ethoxy]indoles has been developed. Best results are obtained in the presence of Pd(OAc)2 and 2-[di(1-adamantyl)phosphanyl]-1-phenylpyrrole as ligand. Subsequent sulfonylation gave novel indole derivatives, which are of interest as potentially biological active 5-HT6 receptor ligands.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Quelle: European Journal of Organic Chemistry | 1 Oct 2008 | 10:52 am CEST

One-Pot Reaction as an Efficient Method for Rigid Molecular Tweezers

Martin Havlík, Vladimír Král, Robert Kaplánek, and Bohumil Dolenský
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol8018067

Quelle: Organic Letters | 1 Oct 2008 | 6:00 am CEST

Studies on the Stereoselective Synthesis of C-Allyl Glycosides

Glenn J. McGarvey, Christopher A. LeClair, and Bahar A. Schmidtmann
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801710s

Quelle: Organic Letters | 1 Oct 2008 | 6:00 am CEST

Is Donor−Acceptor Hydrogen Bonding Necessary for 4,6-O-Benzylidene-directed β-Mannopyranosylation? Stereoselective Synthesis of β-C-Mannopyranosides and α-C-Glucopyranosides

David Crich and Indrajeet Sharma
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol8017038

Quelle: Organic Letters | 1 Oct 2008 | 6:00 am CEST

Highly Regioselective Intermolecular Arylation of 1,2,3,4-Tetrahydropyridines

Guillaume Pelletier, Alexandre Larivée, and André B. Charette
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol8018709

Quelle: Organic Letters | 1 Oct 2008 | 6:00 am CEST

Copper Iodide-Catalyzed Cyclization of (Z)-Chalcogenoenynes

André L. Stein, Diego Alves, Juliana T. da Rocha, Cristina W. Nogueira, and Gilson Zeni
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol802060f

Quelle: Organic Letters | 1 Oct 2008 | 6:00 am CEST

Tandem Palladium-Catalyzed N,C-Coupling/Carbonylation Sequence for the Synthesis of 2-Carboxyindoles

Tiago O. Vieira, Laura A. Meaney, Yong-Ling Shi, and Howard Alper
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801985q

Quelle: Organic Letters | 1 Oct 2008 | 6:00 am CEST

Synthesis and Characterization of Coumarin-Based Spiropyran Photochromic Colorants

Jhih-Rong Chen, Jen-Bing Wong, Pei-Yu Kuo, and Ding-Yah Yang
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol8018902

Quelle: Organic Letters | 1 Oct 2008 | 6:00 am CEST

Regio- and Stereochemistry of [2 + 2] Photocycloadditions of Imines to Alkenes: A Computational and Experimental Study

Diego Sampedro, Alberto Soldevilla, Pedro J. Campos, Roberto Ruiz, and Miguel A. Rodríguez
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo8015242

Quelle: The Journal of Organic Chemistry | 1 Oct 2008 | 6:00 am CEST

A Computational Study of Chlorocarbene Additions to Cyclooctyne

Xiao Yu Mo, Sarah E. Bernard, Marina Khrapunovich, and Dina C. Merrer
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo801736x

Quelle: The Journal of Organic Chemistry | 1 Oct 2008 | 6:00 am CEST

Ring-Opening Reactions of Difluoro(methylene)cyclopropanes with Halogens and Amines

Xiao-Chun Hang, Qing-Yun Chen, and Ji-Chang Xiao
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Note) DOI: 10.1021/jo801610t

Quelle: The Journal of Organic Chemistry | 1 Oct 2008 | 6:00 am CEST

Synthesis of the Phosphinic Analogue of Thyrotropin Releasing Hormone

Magdalini Matziari, Karl Bauer, Vincent Dive, and Athanasios Yiotakis
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Note) DOI: 10.1021/jo8014215

Quelle: The Journal of Organic Chemistry | 1 Oct 2008 | 6:00 am CEST

Fast, Acid-Free, and Selective Lactamization of Lactones in Ionic Liquids

Kristina M. Orrling, Xiongyu Wu, Francesco Russo, and Mats Larhed
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Note) DOI: 10.1021/jo8015264

Quelle: The Journal of Organic Chemistry | 1 Oct 2008 | 6:00 am CEST

Site-Specific Fluorescent Labeling Approaches for Naringenin, an Essential Flavonone in Plant Nitrogen-Fixation Signaling Pathways

Lei Chen, Feng-Qing Li, Bi-He Hou, Guo-Fan Hong, and Zhu-Jun Yao
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo8014165

Quelle: The Journal of Organic Chemistry | 1 Oct 2008 | 6:00 am CEST

Asymmetric Synthesis of 8-Aminoindolizidine from Chiral 2-Pyrroleimines

Vincenzo Giulio Albano, Andrea Gualandi, Magda Monari, and Diego Savoia
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo8014598

Quelle: The Journal of Organic Chemistry | 1 Oct 2008 | 6:00 am CEST

Elimination of β-Thioalkoxy Alcohols under Mitsunobu Conditions. A New Synthesis of Conjugated Enynes from Propargylic Dithioacetals

Chih-Wei Chen and Tien-Yau Luh
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo8013885

Quelle: The Journal of Organic Chemistry | 1 Oct 2008 | 6:00 am CEST

Crucial Role of N···Si Interactions in the Solid-State Coloration of Disilylazobenzenes

Masaki Yamamura, Naokazu Kano, Takayuki Kawashima, Tomonari Matsumoto, Jun Harada, and Keiichiro Ogawa
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo801334a

Quelle: The Journal of Organic Chemistry | 1 Oct 2008 | 6:00 am CEST

The Curtius Rearrangement of Cyclopropyl and Cyclopropenoyl Azides. A Combined Theoretical and Experimental Mechanistic Study

Vinod Tarwade, Olga Dmitrenko, Robert D. Bach, and Joseph M. Fox
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo801104t

Quelle: The Journal of Organic Chemistry | 1 Oct 2008 | 6:00 am CEST

A Convenient Method for the Preparation of Fluorous Tin Derivatives for the Fluorous Labeling Strategy

Jason W. McIntee, Chitra Sundararajan, Amanda C. Donovan, Michael S. Kovacs, Alfredo Capretta, and John F. Valliant
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Article) DOI: 10.1021/jo8013287

Quelle: The Journal of Organic Chemistry | 1 Oct 2008 | 6:00 am CEST

Asymmetric Homologation of Ketones. A New Entry to Orthogonally Protected (2R,4R)-Piperidine-2,4-dicarboxylic Acid

Pablo Etayo, Ramón Badorrey, María D. Díaz-de-Villegas, and José A. Gálvez
Web Release Date: Wed, 1 Oct 2008 00:00:00 EDT (Note) DOI: 10.1021/jo801515k

Quelle: The Journal of Organic Chemistry | 1 Oct 2008 | 6:00 am CEST

Straightforward Strategy for the Stereoselective Synthesis of Spiro-Fused (C-5)Isoxazolino- or (C-3)Pyrazolino-(C-3)quinolin-2-ones from Baylis-Hillman Adducts by 1,3-Dipolar Cycloaddition and Reductive Cyclization

A straightforward and general approach for the stereoselective synthesis of spiro-fused (C-5)isoxazolino- or (C-3)pyrazolino-(C-3)quinolin-2-ones from the adducts offorded from the Baylis-Hillman reaction of 2-nitrobenzaldehyde and ethyl acrylate by sequential 1,3-dipolar cycloaddition and reductive cyclization is presented. It was found that the reductive cyclization of the isoxazoline derivatives proceeded efficiently in the presence of In/HCl, whereas similar reductions of pyrazolines gave better yields when carried out in the presence of an Fe/AcOH mixture. However, similar attempts employing the Baylis-Hillman adduct of 2-nitrobenzaldehyde and methyl vinyl ketone did not yield the desired compounds.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Quelle: European Journal of Organic Chemistry | 30 Sep 2008 | 11:15 am CEST

Microwave-Assisted Stereoselective One-Pot Synthesis of Symmetrical and Unsymmetrical 2,5-Diketopiperazines from Unprotected Amino Acids

The facile condensation of unprotected amino acids by a phosphite-promoted one-step coupling reaction is a highly efficient synthesis to generate stereoselective and optically pure symmetrical and unsymmetrical functionalized diketopiperazines. The use of microwaves enhanced by small amounts of ionic liquid is accompanied by significant improvement in reaction times and yields. Simple filtration through a pad of silica provides the pure compounds in very good to excellent yields.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Quelle: European Journal of Organic Chemistry | 30 Sep 2008 | 11:15 am CEST

Taxpropellane: A Novel Taxane with an Unprecedented Polycyclic Skeleton from the Needles of Taxus canadensis

Taxpropellane, the first example of a taxane with an unprecedented 6/5/5/6/4/5-membered ring hexacyclic skeleton ([3.3.2]propellane), was isolated from the needles of Taxus canadensis. This compound would be derived from a normal 6/8/6 taxane by a [2+2] cycloaddition reaction between the 3,4- and 11,12-double bonds. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Quelle: European Journal of Organic Chemistry | 30 Sep 2008 | 11:15 am CEST

Oxime-Based Synthesis of New Chromogenic and Fluorogenic Oligosaccharides

A new simple approach for the synthesis of labelled oligosaccharides is described. Free synthetic carbohydrate recognition building blocks were conjugated with fluorogenic and chromogenic dyes under mild experimental conditions by using oxime ligation. The resulting oligosaccharide probes presenting well-defined anomer configuration might find broad interests for recognition studies with a large panel of carbohydrate-binding proteins. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Quelle: European Journal of Organic Chemistry | 30 Sep 2008 | 11:15 am CEST

Synthesis and Electrochemical Properties of Structurally Modified Flavin Compounds

Four structurally modified flavin compounds have been synthesized and characterized for their redox potential by chemical reduction with sodium dithionite. Besides the previously reported 1- and 5-deazariboflavin, a 7,8-didemethyl derivative and an 8-isopropylriboflavin have been obtained. The synthesis of these compounds started in all cases from appropriately substituted anilines that were condensed with the ribityl chain, followed by completion of the annealed three-ring structure. The didemethyl- and the isopropyl compounds gave absorption maxima similar to riboflavin (436 and 448 nm, respectively), whereas 1-deazariboflavin showed a bathochromically shifted absorption ([lambda]max = 537 nm), and that of 5-deazariboflavin was hypsochromically shifted ([lambda]max = 400 nm). The midpoint potentials (E0[prime]) of the four modified flavin compounds were determined by potentiometric titration, using riboflavin as a reference compound. Both alkyl-modified flavins showed slightly less negative midpoint potentials, whereas both deaza compounds had more negative midpoint values compared to the reference compound. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Quelle: European Journal of Organic Chemistry | 30 Sep 2008 | 11:15 am CEST

Mono- and Penta-Addition of Enol Silyl Ethers to [60]Fullerene

Eiichi Nakamura, Shinsuke Mouri, Yuki Nakamura, Koji Harano, and Hiroyuki Isobe
Web Release Date: Tue, 30 Sep 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol8020379

Quelle: Organic Letters | 30 Sep 2008 | 6:00 am CEST

Prediction of a New Pathway to Presilphiperfolanol

Selina C. Wang and Dean J. Tantillo
Web Release Date: Tue, 30 Sep 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801898v

Quelle: Organic Letters | 30 Sep 2008 | 6:00 am CEST

Synthesis and Electronic Properties of Conjugated Pentacene Dimers

Dan Lehnherr, Jianbo Gao, Frank A. Hegmann, and Rik R. Tykwinski
Web Release Date: Tue, 30 Sep 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801886h

Quelle: Organic Letters | 30 Sep 2008 | 6:00 am CEST

Versatile Synthesis of Head Group Functionalized Phospholipids via Oxime Bond Formation

Takumi Furuta, Masayoshi Mochizuki, Mai Ito, Tadanobu Takahashi, Takashi Suzuki, and Toshiyuki Kan
Web Release Date: Tue, 30 Sep 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol8019346

Quelle: Organic Letters | 30 Sep 2008 | 6:00 am CEST

Mechanistic and Kinetic Insights into the Thermally Induced Rearrangement of α-Pinene

Achim Stolle, Bernd Ondruschka, and Matthias Findeisen
Web Release Date: Tue, 30 Sep 2008 00:00:00 EDT (Article) DOI: 10.1021/jo8012995

Quelle: The Journal of Organic Chemistry | 30 Sep 2008 | 6:00 am CEST

Glucose-Based Surfactants with Hydrogenated, Fluorinated, or Hemifluorinated Tails: Synthesis and Comparative Physical-Chemical Characterization

Maher Abla, Grégory Durand, and Bernard Pucci
Web Release Date: Tue, 30 Sep 2008 00:00:00 EDT (Featured Article) DOI: 10.1021/jo801379e

Quelle: The Journal of Organic Chemistry | 30 Sep 2008 | 6:00 am CEST

Substituent Effects on the Ring-Opening Mechanism of Lithium Bromocyclopropylidenoids to Allenes

Akin Azizoglu, Metin Balci, Jean-Luc Mieusset, and Udo H. Brinker
Web Release Date: Tue, 30 Sep 2008 00:00:00 EDT (Article) DOI: 10.1021/jo8011144

Quelle: The Journal of Organic Chemistry | 30 Sep 2008 | 6:00 am CEST

Synthesis and Glycosidase Inhibitory Study of New Polyhydroxylated Indolizidines

The synthesis of two polyhydroxylated indolizidines as potenticial glycosidase inhibitors is reported. The piperidine ring was formed by an intramolecular Mannich-type reaction between ethyl trans-4-oxo-2-butenoate and the two [beta]-amino ketones (-)-1-(2-methyl-1,3-dioxan-2-yl)propan-2-amine and(+)-1-(benzyloxymethyl)-2-(2-methyl-1,3-dioxan-2-yl)ethylamine. The synthesis of this amine was performed in eight steps from L-aspartic acid. The key steps of the formation of the framework involved dihydroxylation, nucleophilic substitution, and reduction. The last hydroxy group was introduced by hydrolysis of the acetal moiety followed by reduction of the resulting ketone. The inhibitory properties of the two synthesized indolizidines were evaluated against a variety of commercial glycosidases. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Quelle: European Journal of Organic Chemistry | 30 Sep 2008 | 5:00 am CEST

Enzymatic Method for the Synthesis of Blockbuster Drug Intermediates - Synthesis of Five-Membered Cyclic [gamma]-Amino Acid and [gamma]-Lactam Enantiomers

A very efficient enzymatic method was developed for the synthesis of cyclic [gamma]-lactam and [gamma]-amino acid enantiomers, intermediates for drugs with a prominent turnover (e.g., abacavir and carbovir), through the CAL-B-catalysed enantioselective (E > 200) hydrolysis of the corresponding N-Boc protected and unprotected racemic [gamma]-lactams with H2O in iPr2O. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Quelle: European Journal of Organic Chemistry | 30 Sep 2008 | 5:00 am CEST

Lewis Acid Catalyzed Reactions of Donor-Acceptor Cyclopropanes with Anthracenes

The reactions of 2-aryl-1,1-cyclopropane diesters with anthracene derivatives were studied for the first time. Three kinds of reaction products are formed depending on the nature of the aryl group and the substituents in the anthracene. The first one is the product of [4+3] cycloaddition of cyclopropane to a diene moiety of anthracene. The second one also has a seven-membered ring and is formed by the Lewis acid catalyzed electrophilic attack of cyclopropane onto the C9 atom of anthracene followed by intramolecular attack of the formed arenonium ion on aryl group of the starting cyclopropane. Lastly, the common Friedel-Crafts products are formed. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Quelle: European Journal of Organic Chemistry | 30 Sep 2008 | 5:00 am CEST

Directed (R)- or (S)-Selective Dynamic Kinetic Enzymatic Hydrolysis of 1,2,3,4-Tetrahydroisoquinoline-1-carboxylic Esters

The first synthesis of both enantiomers of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid was accomplished through dynamic kinetic resolution in procedures based on CAL-B- or subtilisin Carlsberg-catalysed enantioselective hydrolysis of the corresponding ethyl esters in aqueous NH4OAc buffer at pH 8.5. The products were obtained with high enantiopurity (92-93 % ee) in good yields (85-92 %). (R)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid was obtained with high enantiopurity (98 % ee) and in good yield (85 %) in a CAL-B-catalysed process, under similar conditions.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

Quelle: European Journal of Organic Chemistry | 30 Sep 2008 | 5:00 am CEST

Synthesis of thienyl analogues of PCBM and investigation of morphology of mixtures in P3HT

Abstract

Novel [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) analogues containing benzo[b]thiophene (3a, 3b) and thieno[3,2-b]thiophene (3c, 3d) were synthesized and characterized. The morphology of the thin films prepared from the mixtures of these methanofullerenes with regioregular poly(3-hexylthiophene) (P3HT) was investigated by AFM measurement and UV-Vis absorption spectroscopy. A solubility test of these methanofullerenes was performed by using dichloromethane as a solvent. es-TThCBM (3d) exhibited 1.4 times greater solubility in dichloromethane than PCBM.

Beilstein J. Org. Chem. 2008, 4, No. 33. doi:10.3762/bjoc.4.33

Quelle: Beilstein Journal of Organic Chemistry | 29 Sep 2008 | 2:00 am CEST

Syntheses of α- and β-C-Glucopyranosyl Serines from a Common Intermediate

Ernest G. Nolen, Laurence A. Donahue, Rebecca Greaves, Trevor A. Daly, and David R. Calabrese
Web Release Date: Sat, 27 Sep 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol802009v

Quelle: Organic Letters | 27 Sep 2008 | 6:00 am CEST

Zwitterionic Phosphonium Sulfonates as Easily Phase-Separable Ion-Tagged Wittig Reagents

Congde Huo, Xun He, and Tak Hang Chan
Web Release Date: Sat, 27 Sep 2008 00:00:00 EDT (Note) DOI: 10.1021/jo801418a

Quelle: The Journal of Organic Chemistry | 27 Sep 2008 | 6:00 am CEST

N-Carbamate Protected α-Amidoalkyl-p-tolylsulfones: Convenient Substrates in the aza-Morita−Baylis−Hillman Reaction

Anna Gajda and Tadeusz Gajda
Web Release Date: Sat, 27 Sep 2008 00:00:00 EDT (Note) DOI: 10.1021/jo801616d

Quelle: The Journal of Organic Chemistry | 27 Sep 2008 | 6:00 am CEST

Hydride Affinities of Cumulated, Isolated, and Conjugated Dienes in Acetonitrile

Xiao-Qing Zhu, Hao Liang, Yan Zhu, and Jin-Pei Cheng
Web Release Date: Sat, 27 Sep 2008 00:00:00 EDT (Article) DOI: 10.1021/jo801536m

Quelle: The Journal of Organic Chemistry | 27 Sep 2008 | 6:00 am CEST

Highly Diastereoselective Addition of Lithio Vinyl Sulfoxides to N-Sulfinimines: An Entry to Enantiopure 3-Sulfinyl-2,5-cis-dihydropyrroles

Alma Viso, Roberto Fernández de la Pradilla, Mercedes Ureña, and Ignacio Colomer
Web Release Date: Sat, 27 Sep 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801878f

Quelle: Organic Letters | 27 Sep 2008 | 6:00 am CEST

TEMPO/NaIO4−SiO2: A Catalytic Oxidative Rearrangement of Tertiary Allylic Alcohols to β-Substituted α,β-Unsaturated Ketones

Masatoshi Shibuya, Masaki Tomizawa, and Yoshiharu Iwabuchi
Web Release Date: Sat, 27 Sep 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol801673r

Quelle: Organic Letters | 27 Sep 2008 | 6:00 am CEST

Total Synthesis of (+)-Lepadin F

Gang Li, Richard P. Hsung, Brian W. Slafer, and Irina K. Sagamanova
Web Release Date: Sat, 27 Sep 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol802068q

Quelle: Organic Letters | 27 Sep 2008 | 6:00 am CEST

Synthesis and Biological Evaluation of a Phosphonate Analog of the Natural Acetyl Cholinesterase Inhibitor Cyclophostin

Saibal Bandyopadhyay, Supratik Dutta, Christopher D. Spilling, Cynthia M. Dupureur, and Nigam P. Rath
Web Release Date: Sat, 27 Sep 2008 00:00:00 EDT (Article) DOI: 10.1021/jo801453v

Quelle: The Journal of Organic Chemistry | 27 Sep 2008 | 6:00 am CEST

Povarov Reactions Involving 3-Aminocoumarins: Synthesis of 1,2,3,4-Tetrahydropyrido[2,3-c]coumarins and Pyrido[2,3-c]coumarins

Amit A. Kudale, Jamie Kendall, David O. Miller, Julie L. Collins, and Graham J. Bodwell
Web Release Date: Sat, 27 Sep 2008 00:00:00 EDT (Article) DOI: 10.1021/jo801411p

Quelle: The Journal of Organic Chemistry | 27 Sep 2008 | 6:00 am CEST

Oxidative Aromatization of Olefins with Dioxygen Catalyzed by Palladium Trifluoroacetate

John E. Bercaw, Nilay Hazari, and Jay A. Labinger
Web Release Date: Sat, 27 Sep 2008 00:00:00 EDT (Note) DOI: 10.1021/jo8016296

Quelle: The Journal of Organic Chemistry | 27 Sep 2008 | 6:00 am CEST

Asymmetric Mukaiyama Aldol Reaction of Nonactivated Ketones Catalyzed by allo-Threonine-Derived Oxazaborolidinone

Shinya Adachi and Toshiro Harada
Web Release Date: Fri, 26 Sep 2008 00:00:00 EDT (Letter) DOI: 10.1021/ol802087u

Quelle: Organic Letters | 26 Sep 2008 | 6:00 am CEST