Chemie der Uebergngsmetalle - Aktuelle Forschungsartikel renommierter Fachzeitschriften
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beruecksichtige naturwissenschaftliche Journale:
Transition Metal Chemistry - published by
Springer Netherlands -
... is an international journal dealing with all aspects of the preparation of transition metal-based compounds of all kinds, their structural, physical, kinetic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems and more.
Aktuelle wissenschaftliche Fachartikel der
genannten Journale:
A bidentate ligand, 5-chloro-2-(phenylazo)pyridine (Clazpy), and its two polypyridyl ruthenium(II) complexes, [Ru(Clazpy)2bpy]Cl2·7H2O (1) and [Ru(Clazpy)2phen]Cl2·8H2O (2), were synthesized and characterized. The DNA-binding properties of these complexes with DNA, the breast cancer susceptibility
gene 1 (BRCA1), and the pBIND plasmid DNA were probed by photocleavage, electronic absorption titration, ethidium bromide quenching, and
thermal denaturation. Both complexes were found to bind to the BRCA1 fragment through the intercalative mode into the base pairs of DNA, and the DNA-binding constants (Kb) for 1 and 2 were 7.0 × 104 M−1 and 5.1 × 105 M−1, respectively. In addition, both complexes enhanced the single-stranded cleavage of the plasmid DNA. Under comparable experimental
conditions, 2 cleaved DNA more effectively than 1, in a dose–response manner. The data indicated that the binding affinity of these two complexes to DNA was dependent on the
aromatic planarity and hydrophobicity of the intercalative polypyridyl ligand.
Content Type Journal Article
Pages 1-8
DOI 10.1007/s11243-012-9576-5
Authors
Adisorn Ratanaphan, Laboratory of Pharmaceutical Biotechnology, Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand
Tidarat Nhukeaw, Laboratory of Pharmaceutical Biotechnology, Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand
Pornvichai Temboot, Laboratory of Pharmaceutical Biotechnology, Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand
Kanidtha Hansongnern, Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand
Three diiron carbonyl complexes, namely [(η5-C5H4)(η3-C(CH2)2)]Fe2(CO)5 (1), [(C2H5)2C(η5-C5H4)2]Fe2(μ-CO)2(CO)2 (2), and [(CH2)4C(η5-C5H4)(η5-C5H3)(C5H9)]Fe2(μ-CO)2(CO)2 (3), have been synthesized by the reactions of C5H4C(Me)2, C5H4C(Et)2, and C5H4C(CH2)4, respectively, with Fe(CO)5 in refluxing xylene. The complexes have been characterized by elemental analysis, IR, and 1H NMR spectra. The molecular structures of the complexes have been determined by single-crystal X-ray diffraction. The structures
of the complexes indicate that fulvenes can be bound to transition metal centers by diverse modes.
Content Type Journal Article
Pages 1-6
DOI 10.1007/s11243-011-9557-0
Authors
Zhi-Hong Ma, College of Basic Medicine, Hebei Medical University, Shijiazhuang, 050017 People’s Republic of China
Li-Juan Tian, The College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang, 050016 People’s Republic of China
Su-Zhen Li, Hebei College of Industry and Technology, Shijiazhuang, 050091 People’s Republic of China
Zhan-Gang Han, The College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang, 050016 People’s Republic of China
Xue-Zhong Zheng, The College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang, 050016 People’s Republic of China
Jin Lin, The College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang, 050016 People’s Republic of China
Two ruthenium(II) polypyridyl complexes, namely [Ru(phen)2(DMDPPZ)](ClO4)21 (phen = 1,10-phenanthroline, DMDPPZ = 3,6-dimethyldipyrido[3,2-a:2′,3′-c]phenazine) and [Ru(dmp)2(DMDPPZ)](ClO4)22 (dmp = 2,9-dimethyl-1,10-phenanthroline), have been synthesized and characterized. The DNA-binding properties of the complexes
were investigated by spectrophotometric methods, viscosity measurements, and photoactivated cleavage studies. The DNA-binding
constants for complexes 1 and 2 have been determined as 8.78 (±0.94) × 105 M−1 (s = 3.02) and 1.26 (±0.35) × 105 M−1 (s = 1.69), respectively. The results suggest that these complexes bind to calf thymus DNA through intercalation. When irradiated
at 365 nm, the complexes promote the photocleavage of pBR322 DNA, and complex 1 cleaves DNA more effectively than complex 2 under comparable experimental conditions. The cytotoxicities of complexes 1 and 2 have been evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) method. Complex 2 shows higher anticancer potency than complex 1 against four tumor cell lines. The apoptosis-inducing activity was assessed by acridine orange/ethidium bromide staining
assay, and the antioxidant activities of these complexes against hydroxyl radical were also explored.
Content Type Journal Article
Pages 1-9
DOI 10.1007/s11243-011-9575-y
Authors
Li Xu, School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, 528458 People’s Republic of China
Yang-Yin Xie, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006 People’s Republic of China
Nan-Jing Zhong, School of Food Science, Guangdong Pharmaceutical University, Zhongshan, 528458 People’s Republic of China
Zhen-Hua Liang, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006 People’s Republic of China
Juan He, School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, 528458 People’s Republic of China
Hong-Liang Huang, School of Life Science and Biopharmacological, Guangdong Pharmaceutical University, Guangzhou, 510006 People’s Republic of China
Yun-Jun Liu, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006 People’s Republic of China
The substitution of bis(2,4,6-tripyridyl 1,3,5-triazine)iron(II),
\textFe(TPTZ) 2 2 +
by 2,2′,6,2″-terpyridine (terpy) occurs on a time scale of about 6 m. The kinetics of this reaction was followed by stopped-flow
spectrophotometry in the pH range of 3.6–5.6 in acetate buffer. The data indicate that the reaction occurs in two consecutive
steps: kinetic data for both steps were acquired simultaneously and analyzed independently. The first step is assigned to
the reaction between
\textFe(TPTZ) 2 2 +
and terpy to give Fe(TPTZ)(terpy)2+, followed by its reaction with another terpy molecule to give the final product,
\textFe(terpy) 2 2 +
. The rate of the reaction increases with increases in [terpy] and pH. The kinetic and activation parameters determined for
both steps suggest that they involve both associative and dissociative paths. The ternary complex Fe(TPTZ)(terpy)2+ has been prepared, and the kinetics of its reaction with terpy suggest that this reaction is identical with the second step
of the
\textFe(TPTZ) 2 2 +
-terpy system, supporting the proposed mechanism.
Content Type Journal Article
Pages 1-8
DOI 10.1007/s11243-011-9574-z
Authors
Garimella Visweswara Rao, Department of Physical and Nuclear Chemistry and Chemical Oceanography, Andhra University, Visakhapatnam, 530 003 India
Rajesh Bellam, Department of Physical and Nuclear Chemistry and Chemical Oceanography, Andhra University, Visakhapatnam, 530 003 India
Nageswra Rao Anipindi, Department of Physical and Nuclear Chemistry and Chemical Oceanography, Andhra University, Visakhapatnam, 530 003 India
Three 1,3-dialkylimidazolinium chloride salts and their palladium(II) complexes have been synthesized and characterized by
elemental analysis, 1H NMR, 13C NMR and IR spectroscopy. The catalytic activities of the 1,3-dialkylimidazolinium chloride salts and their complexes in
the Heck and Suzuki coupling reactions were investigated.
Content Type Journal Article
Pages 1-6
DOI 10.1007/s11243-011-9573-0
Authors
Beyhan YiÄŸit, Department of Chemistry, Faculty of Science and Art, Adiyaman University, 02040 Adiyaman, Turkey
A series of distorted square planar palladium(II) complexes with dithiocarbamic acids of general formula [Pd(L)2], where L = 4-methylpiperazine-l-carbodithioic acid anion, morpholine-4-carbodithioic acid anion or 4-benzylpiperidine-l-carbodithioic
acid anion for complexes 1a, 1b and 1c, respectively, have been synthesized. The complexes were characterized by physicochemical and spectroscopic methods; in addition,
the structure of complex 1a was characterized by single crystal X-ray crystallography. The interaction of these palladium complexes with CT-DNA was investigated
with the help of absorption and emission spectroscopy. The association constant Kb was deduced from the absorption spectra, while the number of binding sites and the binding constant were calculated from
the fluorescence quenching data. The results suggest an intercalative interaction of the complexes with CT-DNA.
Content Type Journal Article
Pages 1-7
DOI 10.1007/s11243-011-9569-9
Authors
Titas Mukherjee, Department of Chemistry, Burdwan University, Golapbag, Burdwan, 713104 India
Sandipan Sarkar, Department of Chemistry, Burdwan University, Golapbag, Burdwan, 713104 India
The kinetics of metal exchange between copper(II) and tetramethylenediaminetetraacetatonickel(II), [Ni(TMDTA)] has been studied
between pH 3.4 and 4.8 at an ionic strength of 1.25 M (NaClO4) and a temperature of 25.0 ± 0.1 °C. The reaction is first order in [Ni(TMDTA)]. The reaction order in [Cu2+] varies from first to zero and then back to first as [Cu2+] is increased. At low copper concentration, the first-order rate constant is pH independent and represents the attack of
copper on the nickel complex through a pathway in which TMDTA is partially uncoordinated before reaction with copper. Evidence
is presented for a stepwise dechelation mechanism followed by attack of copper to give a dinuclear intermediate. The zero-order
rate is pH dependent. At higher [Cu2+], the swing back to first order is due to the formation of a weak copper-tetramethylenediaminetetraacetatonickelate complex
which then converts to products through a dinuclear intermediate. A plausible mechanism, consistent with all the kinetic data,
is presented.
Content Type Journal Article
Pages 1-6
DOI 10.1007/s11243-011-9570-3
Authors
Radhey Mohan Naik, Department of Chemistry, Lucknow University, Lucknow, 226007 UP, India
Abhas Asthana, Department of Chemistry, Lucknow University, Lucknow, 226007 UP, India
Richa Rastogi, Department of Chemistry, Lucknow University, Lucknow, 226007 UP, India
A new Cu(II) complex, [Cu(naph-val)phen] (naph-val = Schiff base derived from 2-hydroxy-1-naphthaldehyde and l-valine, phen = 1,10-phenanthroline), has been synthesized and characterized by physicochemical methods. The crystal structure
of the complex showed that there are four independent molecular structures in the crystallographic asymmetric unit, and each
of them shows a distorted square-pyramidal CuN3O2 coordination geometry. In the crystal, the π − π stacking and intermolecular hydrogen bonds form a 2D network. The interactions
between the Cu(II) complex and calf thymus DNA (CT-DNA) have been studied by spectroscopic methods, as well as viscosity and
thermal denaturation measurements. The results indicate that the Cu(II) complex binds to CT-DNA in an intercalative mode.
The cleavage reaction on pBR322 plasmid DNA has been investigated by agarose gel electrophoresis in the absence and presence
of mercaptopropionic acid. The Cu(II) complex exhibits an efficient DNA cleavage activity.
Content Type Journal Article
Pages 1-8
DOI 10.1007/s11243-011-9572-1
Authors
Jinghong Li, Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059 People’s Republic of China
Jianfang Dong, Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059 People’s Republic of China
Hui Cui, Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059 People’s Republic of China
Tao Xu, Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059 People’s Republic of China
Lianzhi Li, Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, 252059 People’s Republic of China
A Schiff base (HL) has been synthesized and characterized by physico-chemical, spectroscopic and X-ray crystallography studies.
Three of its Ru(III) complexes were synthesized and characterized by analytical and spectroscopic studies. The DNA binding
properties of HL and its Ru(III) complexes have been investigated by electronic absorption spectroscopy. Also, HL and its
Ru(III) complex [RuCl2(AsPh3)L] were tested for DNA cleavage properties. The results showed that the complex cleaves DNA more rapidly than the free ligand.
Further, an in vitro study of the cytotoxicity of HL and the complex [RuCl2(AsPh3)L] was carried out.
Content Type Journal Article
Pages 1-6
DOI 10.1007/s11243-011-9571-2
Authors
Gunasekaran Raja, Post-Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore, 641 020 Tamil Nadu, India
Ray J. Butcher, Department of Chemistry, Howard University, Washington, DC 20059, USA
Chinnasamy Jayabalakrishnan, Post-Graduate and Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore, 641 020 Tamil Nadu, India
Efficient Suzuki–Miyaura cross-coupling reactions of arylboronic acids with aryl halides catalyzed by Pd/N,N,O-tridentate
ligands, using methanol as solvent and K3PO4 as base, afforded the corresponding cross-coupled biaryls in good to excellent yields.
Graphical Abstract
The Pd(OAc)2/N,N,O-tridentate ligands system was found to be very efficient for Suzuki reactions involving aryl bromides and activated
aryl chlorides with arylboronic acid in methanol with K3PO4 as a base at 80 °C for 3 h. The mechanism of the Suzuki reactions along with the Suzuki-type self-coupling reaction catalyzed
by these catalyst systems also proposed.
Content Type Journal Article
Pages 1-5
DOI 10.1007/s11243-011-9568-x
Authors
Zhonggao Zhou, College of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, 341000 People’s Republic of China
Ziyi Du, College of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, 341000 People’s Republic of China
Qiaosheng Hu, College of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, 341000 People’s Republic of China
Jicheng Shi, College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, 350007 People’s Republic of China
Yongrong Xie, College of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, 341000 People’s Republic of China
Yulan Liu, College of Architecture and Environment, Sichuan University, Chengdu, 610207 People’s Republic of China
A series of 1,2-diacyl cyclopentadienyl tricarbonyl manganese and rhenium complexes, [M(CO)3{η5-1,2-C5H3(CO-(R)2}] (3a–c and 4a–b), were isolated utilizing a straightforward, 3-step route. The synthetic pathway began with a 1,2-diacyl cyclopentadiene
(fulvene), followed by the formation of its corresponding thallium salt and transmetallation with the appropriate pentacarbonyl
metal bromide. X-ray crystallographic analysis and high-accuracy mass spectrometry confirmed the structures of the both the
4-methoxyphenyl and 4-chlorophenyl diacyl rhenium complexes, [Re(CO)3{η5-1,2-C5H3(CO-(4-OCH3)C6H4)2}] (4a) and [Re(CO)3{η5-1,2-C5H3(CO-(4-Cl)C6H4)2}] (4b). Diacyl complexes 3a–c and 4a–b were then ring-closed with hydrazine hydrate to form their corresponding pyridazine complexes, [M(CO)3{η5-1,2-C5H3(1,4-(R)2N2C2}] (5a–c and 6a–b), in good yields (60–83%). The pyridazyl ligands were found to be relatively labile, and recrystallization of the target
complexes 5a–c and 6a–b afforded only the free pyridazine ligands.
Content Type Journal Article
Pages 1-7
DOI 10.1007/s11243-011-9567-y
Authors
Nathan C. Tice, Department of Chemistry, Butler University, 4600 Sunset Avenue, Indianapolis, IN 46208, USA
Chad A. Snyder, Department of Chemistry, Western Kentucky University, 1906 College Heights Blvd., Bowling Green, KY 42101, USA
Andrew Z. Preston, Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
Marika B. Wieliczko, Department of Chemistry, Emory University, Atwood Hall, 1515 Dickey Drive, Atlanta, GA 30322, USA
Jason O. E. Young, Department of Chemistry, Western Kentucky University, 1906 College Heights Blvd., Bowling Green, KY 42101, USA
Daniel F. Hinson, Department of Chemistry, Western Kentucky University, 1906 College Heights Blvd., Bowling Green, KY 42101, USA
